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Phamocology Test 2

drug cards

QuestionAnswer
Peak highest concentration of a drug in the bloodstream indicating the maximum therapeutic effect. (Check 1hr or more after admin).
Troph (trough level) lowest concentration of drug in the bloodstream. (Check before the next dose is administered).
C&S Culture and sensitivity: Must be done before IV antibiotic therapy. (Determines microorganism causing the infection).
Diarrhea Normal intestinal bacteria being destroyed
Superinfection (secondary infection) occurs during or after antibiotic treatment Ex: C. diff, thrush, candida albicans (yeast), vaginal discharge.
eosinophils Fights off infections and contributes to allergic reactions
Aminoglycosides: Example and Usage 1. Amikacin, Gentamicin, Streptomycin, Tobramycin. 2. Used when penicillin CANNOT be. Ends in "micin"
Aminoglycosides: Indications 1. Treats serious aerobic (requires O2) gram- infections 2. Used primarily when penicillin has not worked or is contraindicated. 3. Used in surgical cases
Aminoglycosides: Adverse Reaction Not given orally due to poor oral absorption 1. Nausea, vomiting, diarrhea 2. Muscle paralysis (priority reaction)
Aminoglycosides: Associated Labs Renal function (BUN, Cr), C&S, Peak, Troph, Electrolytes -> when given via IV
Aminoglycosides: Nurse Considerations Monitor: signs of new/superinfections (ex: C. diff,), Ototoxicity (irreversible), Nephrotoxicity (reversible), Longterm use leads to liver cirrhosis, DO NOT used with penicillin, Causes fetal harm, DO NOT BREASTFEED, Potential for warfarin toxicity
Aminoglycosides: Patient Education Drink plenty of water (2,000 - 3,000 extra mL per day) to decrease accumulation of drug in kidneys
Penicillin: Examples and Usage 1. Amoxicillin = Augmentin, Piperacillin, Ampicillin = Unasyn (end in "cillin") 2. Mostly effective against gram+ infections and disrupts cell wall synthesis 3. Treats many infections (mostly ear infections)
Penicillin: Adverse reactions (besides nausea, vomiting, and diarrhea) Angioedema (lips/tongue swell), Steven Johnson Syndrome, skin rash, urticaria (hives), pruritus (itching), phlebitis
Penicillin: Associated Labs May elevate Liver Function (ALT/AST) when given IV
Penicillin: Nursing Considerations 1. Give with full glass of water on empty stomach 2. Acidic juice destroys penicillin 3. Use caution if allergic to cephalosporin or taking beta blockers 4. Phlebitis at injection site 5. Monitor for anaphylaxis and superinfections (thrush/yeast)
Penicillin: Patient Education 1. May decrease effectiveness of birth control pills. Use extra method 2. May increase effectiveness of coumadin
Penicillin: Extra Precautions (Black Box) 1. Cross sensitivity to Cephalosporins: 10% allergic to penicillin = reaction to cephalosporins 2. Adjust dose in renal impairment (reduces accumulation and toxicity) 3. Check for BLEEDING -> if on anticoagulants, increased INR is possible with coumadin
Steven Johnson Syndrome (SJS) Flu-like symptoms, purple/red BLISTERS on the back and neck, decreased blood pressure, and throbbing joints
Cephalosporins: Examples and Uses 1. 1st generation: Ancef, Keflex (treats gram+) 2. 3rd generation: Cefobid, Cefzil, Claforan, Fortaz, Rocephin 3. Broad spectrum treatment for many different types of bacterial infections
Cephalosporins: Adverse reactions (besides of nausea, vomiting, and diarrhea) C. diff, Pain at IM site, Phlebitis at IV site, SJS
Cephalosporins: Associated Labs Renal function (BUN, Cr) when given IV
Cephalosporins: Nursing Considerations 1. Cross reaction in those allergic to penicillin 2. May decrease effectiveness of birth control
Cephalosporins: Patient Education 1. Drink plenty of fluids 2. Avoid alcohol and OTC cough syrups to eliminate Antabuse-like reaction 3. Report rash, swelling, or pain at the IV/IM site
Cephalosporins: Black Box 1. Reports of burning or pain at IV administration, stop infusion immediately. 2. No alcohol during and 72 hrs after treatment (Antabuse effect)
beta Lactams/Carbapenems: Examples and Uses 1. Azactam 2. Broad spectrum antibacterial agent used similarly to penicillin 3. Can be given IM/IV
beta Lactams/Carbapenems: Adverse reactions (besides nausea, vomiting, and diarrhea) Rash, Increased sweating, C. diff, Possible drug induced seizures
beta Lactams/Carbapenems: Associated Labs Renal function (BUN Cr), Liver function (ALT/AST), C&S when given IV, Decreases valproic acid levels = increased seizures, May decrease hemoglobin and hematocrit levels (H&H)
beta Lactams/Carbapenems: Nursing Considerations 1. Do NOT give with aminoglycosides 2. Use cautiously when allergic or sensitive to penicillin and cephalosporin 3. Small risk of drug induced seizures
beta Lactams/Carbapenems: Patient Education 1. Do NOT take with fruit juice or carbonated beverages 2. Drink plenty fluids 3. Notify provider of GI upset
beta Lactams/Carbapenems: Black Box 1. Nephrotoxicity if combined with aminoglycosides 2. Monitor for seizures in those with history of CNS disorders or renal dysfunction
Chelation Rule minerals/supplements that binds medicine to the gut and makes it difficult to absorb.
Fluoroquinolones/Quinolones: Cheat Sheet Flox the tendons fear the sun, avoid dairy, and stops if pain starts.
Fluoroquinolones/Quinolones: Examples and Uses 1. Cipro = ciprofloxacin, Levaquin = levofloxacin, Moxifloxacin 2. Broad spectrum antibiotic used to treat bronchitis, pneumonia, and UTIs 3. Ends in "floxacin"
Fluoroquinolones/Quinolones: Adverse reaction (besides nausea, vomiting, and diarrhea) SJS, tendon rupture
Fluoroquinolones/Quinolones: Associated Labs Renal function (BUN Cr), Liver function (ALT/AST), when given via IV. May decrease glucose levels
Fluoroquinolones/Quinolones: Nursing Considerations 1. Drink plenty fluids (prevent crystalluria) 2. Give 1hr prior or 2hrs after meals/other meds 3. DO NOT give to Peds 4. Avoid in clients with heart rhythm disturbances (prolongs QT interval/aortic aneurysm) 5. Seizures 6. Can affect Vitamin K synthe
Fluoroquinolones/Quinolones: Patient Education 1. May discolor urine 2. Use sunscreen due to photosensitivity 3. No dairy or tube feeding (reduces absorption) 4. Avoid caffeine and antacids. 5. Avoid iron, zinc, magnesium, aluminum, and Carafate a minimum of 2hrs before or 2hrs after taking
Fluoroquinolones/Quinolones: Black Box 1. Peripheral neuropathy (may be permanent), monitor for tingling or numbness 2. Do NOT give to Peds due to risk of joint/tendon issues 3. Absorption is significantly reduced with dairy, iron, antacids, and Carafate
Cyclic lipopeptide: Examples and Uses 1. Daptomycin (cubicin) 2. Treats severe gram+ bacterial infections including MRSA (used for skin/skin structure infections and bacteremia associated with endocarditis)
Cyclic lipopeptide: Adverse reactions Rhabdomyolysis (muscle breakdown)
Cyclic lipopeptide: Associated Labs Creatine Phosphokinase (CPK)
Cyclic lipopeptide: Nursing Considerations Should NOT be given to patients with pneumonia
Oxazolidinones: Examples and Uses 1. Zyvox 2. Used to treat infections associated with VRE or MRSA
Oxazolidinones: Adverse Reactions (besides nausea, vomiting, and diarrhea) Headache, C. diff, Altered taste, Vein irritation, Insomnia, Optic neuropathy
Oxazolidinones: Associated Labs Renal function (BUN Cr), Liver function (ALT/AST) when given via IV, May decrease glucose, May decrease platelets
Oxazolidinones: Nursing Considerations Monitor for serotonin syndrome in those taking MAOIs, SSRIs, TCAs
Oxazolidinones: Patient Education 1. Patients need to consume small, frequent meals while taking 2. immediately report vision changes 3. Monitor for thigh and calf pain (lactic acidosis)
Oxazolidinones: Black Box 1. Prolonged use = increased optic neuropathy risk 2. NOT 1st LINE, only use when resistance is suspected 3. Serotonin Syndrome symptoms include agitation, confusion, tremor/muscle rigidity, hypothermia
Sulfonamides: Examples and Uses 1. Bactrim, Septra 2. Bacteriostatic = inhibits folic acid synthesis 3. Treats many infections: UTIs, ear, ulcerative colitis
Sulfonamides: Adverse Reactions (besides nausea, vomiting, diarrhea) SJS, Headache, Stomatitis (stomach, tongue, lips), delayed cutaneous reaction, photosensitivity.
Sulfonamides: Associated Labs Renal Function (BUN Cr), Liver Function (ALT/AST), Leukopenia (may be confused for a cold), Thrombocytopenia (platelet count less than 100,000)
Sulfonamides: Nursing Considerations 1. Use caution with anyone who is allergic to sulfa products 2. Increases Dilantin levels
Sulfonamides: Patient Education 1. Do NOT take pregnant/give to infants under 2 months 2. Use alternative form of birth control (condoms) 3. Take with a full glass of water 4. Avoid prolonged exposure to the sun
Sulfonamides: Black Box 1. May falsely present a cold (leukopenia symptoms = fever, fatigue, sore throat, cough) 2. May cause kernicterus (bilirubin toxicity) during pregnancy and infancy 3. Monitor for signs of increased Dilantin (phenytoin) = toxicity
Tetracyclines: Examples and Uses 1. Tetracycline, Doxycycline 2. Used to treat bacterial infections like Rocky Mountain spotted fever, Lyme disease, acne in adolescents/adults 3. Kills bacteria out right and stops the growth
Tetracyclines: Adverse Reactions (besides nausea, vomiting, and diarrhea) 1. Vertigo 2. Thrombophlebitis at IV site 3. Photosensitivity
Tetracyclines: Associated Labs 1. Liver function (ALT/AST) when given via any route during long term use 2. Increases BUN levels depending on dosage
Tetracyclines: Nursing Considerations 1. Give 1hr before or 2hrs after meals 2. Give with full glass of water and sit them upright for a 30 mins 3. NO DAIRY (chelation rule: magnesium, metal, milk, minerals) 4. Must only use Doxycycline if a renal patient
Tetracyclines: Patient Education 1. Photosensitivity: use sunscreen 2. Take on empty stomach/avoid dairy 3. Avoid if pregnant/nursing/under 8 years old (teeth discoloring) 4. Avoid iron/calcium supplements, MVIs, antacids, laxatives within 2hrs of use due to decreased effectiveness
Tetracyclines: Black Box 1. Permanent teeth discoloration in children under 8 2. Extreme sun sensitivity 3. Chelation rule: separate from supplements and laxatives 4. May potentiate anticoagulants and weaken oral contraceptives
Macrolides: Examples and Uses 1. Erythromycin, Azithromycin = zithromax, Clarithromycin = biaxin, Fidaxomicin = C. diff treatment 2. Work horse for respiratory infections 3. End in "mycin/micin"
Macrolides: Adverse reaction (besides nausea, vomiting, and diarrhea) 1. GI bleed 2. Tinnitus 3. QT prolongation 4. Abnormal Taste 5. Decreased appetite
Macrolides: Associated Labs Renal Function (BUN Cr), Liver function (ALT/AST) when given IV, potentiates Tegretol, Digoxin, Coumadin, and Theophylline effectiveness/levels as well as sedative effects of medications
Macrolides: Nursing Considerations 1. Use cautiously in those taking sulfonamides and theophylline 2. Concurrent use of simvastatin/lovastatin with clarithromycin or erythromycin is not recommended
Macrolides: Patient Education 1. Photosensitivity = exaggerated sunburn (use sunscreen) 2. Drink plenty fluids 3. Take on empty stomach when possible 4. Use another form of birth control (condoms)
Macrolides: Black Box 1. DO NOT TAKE WITH STATINS = muscle toxicity 2. Serious interactions with sulfonamides/theophylline 3. QT prolongation/risk of arrhythmia (chest pains, dizziness, or palpitations = assess) 4. Potentiates levels of several drugs (monitor for toxicity)
Lincosamides: Examples and Uses 1. Lincomycin = lincocin, Clindamycin =cleocin 2. Treats several different infections 3. All Enterobacteriaceae are RESISTANT TO CLINDAMYCIN
Lincosamides: Adverse reaction (besides nausea, vomiting, and diarrhea) 1. C. diff 2. Phlebitis at IV site 3. Blood dyscrasias 4. Hypotension 5. Pseudomembranous colitis (antibiotic associated colitis) 6. Vertigo
Lincosamides: Associated Labs 1. Decreased leukocytes, eosinophils, platelets 2. Liver function (ALT/AST) when given IV
Lincosamides: Nursing Considerations 1. Bitter taste 2. Thin layer for topical application
Lincosamides: Patient Education 1. Drink plenty fluids 2. Take with or without meals 3. Use alternative birth control (condoms)
Lincosamides: Black Box 1. Caution with GI history: high C. diff risk with Clindamycin due to colitis 2. Topical formulations are flammable: emphasize fire safety 3. Follow with water or mix with small food if allowed to alleviate bitter taste
Glycopeptide: Examples and Uses 1. Vancomycin, Bleomycin 2. Vancomycin (IV only) = most popular 3. Treats multi-resistant MRSA/enterococcal infections resistant to beta-lactams 4. Inhibits bacteria cell wall formation by stopping peptidoglycan synthesis 5. End in "mycin/cin"
Glycopeptide: Adverse reaction 1. Redman syndrome = flat, red rash on neck and upper torso 2. Nephrotoxicity 3. Neutropenia 4. Deafness (reversible)/ear ringing = stop, check troph, notify Dr.
Glycopeptide: Associated Labs 1. Peak (25-50) and Troph (10-20) 2. BUN Cr / GFR 3. Platelets
Glycopeptide: Nursing Considerations 1. Phlebitis at site 2. Fluid intake 3. Monitor reactions/labs
Glycopeptide: Patient Education 1. Drink plenty fluids 2. Report any signs/symptoms of reactions 3. Labs are important
Glycopeptide: Black Box 1. Redman Syndrome = rapid infusion - always infuse Vancomycin slow (over 60-90 mins) 2. Hearing checks for long term users/high doses 3. Rotate site/access often (prevents phlebitis) 4. Adjust dose in renal patients - based on troph/kidney function
Antifungals: Examples and Uses 1. Amphotericin B, Diflucan, Monistat, Nizoral, Mycostatin, Nystatin 2. Treats fungal infections
Antifungals: Adverse reaction 1. Malaise (tired) 2. Headache 3. Lack of appetite/dyspepsia (acid reflux/indigestion) 4. Angioedema (facial edema) 5. Hepatoxicity 6. Nephrotoxicity
Antifungals: Associated Labs WHEN GIVEN IV 1. Potassium - hypokalemia 2. Magnesium - hypomagnesemia 3. Renal (BUN, Cr) 4. Liver (ALT/AST)
Antifungals: Nursing Considerations 1. Protect Amphotericin B from sunlight - cover package/tubing 2. Monitor for fever/chills after IV admin 3. Phlebitis at site 4. Use cautiously when taking steroids
Antifungals: Patient Education 1. May cause gynecomastia in long term use 2. NO TOOTHPICKS - may increase incidence of bleeding 3. Practice good oral hygiene 4. Consume small, frequent meals 5. Swish and swallow
Antifungals: Black Box 1. Rotate sites and infuse slowly to prevent phlebitis 2. Premedicate if ordered for fever and chills post IV dose 3. May increase fungal resistance/toxicity if taking steroids
Antihelmintics: Examples and Uses 1. Provan, Vermox, Albendazole, Praziquantel (specific medications treat specific infections) 2. Dewormer 3. Destroys amebiasis, roundworms, hookworms, pinworms
Antihelmintics: Adverse reaction (besides nausea, vomiting, and diarrhea) 1. Abdominal bloating 2. Anorexia
Antihelmintics: Associated Labs Sampling stool, blood, urine, sputum, or tissue for ova/larva
Antihelmintics: Nursing Considerations STRICT HANDWASHING
Antihelmintics: Patient Education 1. Treat entire family regardless of who is infected 2. Wash utensils and linen in hottest water possible 3. Vermox is most effective when chewed and taken with fatty meals
Antihelmintics: Black Box 1. Reinfection = common. Stress personal/environment hygiene 2. Asymptomatic carrier can infect too, treat ALL in close contact 3. Fatty meals improve absorption 4. DO NOT use OTC dewormers unless instructed (specific meds treat specific infections)
Antimalarials/Antiprotozoals: Examples and Uses 1. Plaquenil (hydroxychloroquine), Quinine (qualaquin) 2. Treats malaria
Antimalarials/Antiprotozoals: Adverse reaction (besides nausea, vomiting, and diarrhea) 1. Tinnitus 2. Orthostatic hypotension 3. Increase thirst 4. Leg cramps
Antimalarials/Antiprotozoals: Associated Labs 1. G6PD test for African Americans/Mediterranean descent prior to admin (detects myosteniogravis/muscle breakdown) 2. Liver Function (ATL/AST)
Antimalarials/Antiprotozoals: Nursing Considerations 1. May lower seizure threshold depending on dose and duration 2. No antacids within 4hrs of admin 3. Check for depressed deep tendon reflex if long term use
Antimalarials/Antiprotozoals: Patient Education 1. If only taken weekly, take on the same day around the same time 2. Take with food
Antimalarials/Antiprotozoals: Black Box 1. Risk of neurotoxicity: assess deep tendon reflexes 2. Use caution in those with seizures (lowered threshold) 3. Antacids interfere with absorption (separate by 4hrs) 4. Test G6PD deficiency to avoid hemolytic anemia
Antiparasitics: Examples and Uses 1. Lindane (Kwell), RID, NIX 2. Causes paralysis amd death of parasite, particularly lice and scabies, by attacking the nervous system 3. Treats pubic/body lice
Antiparasitics: Adverse reaction 1. Skin irritation (itching/burning) 2. Transient dizziness 3. Most adverse effects are due to product misuse
Antiparasitics: Associated Labs NONE
Antiparasitics: Nursing Considerations 1. Use cautiously in those with seizures 2. Ensure skin is cool prior to application
Antiparasitics: Patient Education 1. TREAT ENTIRE FAMILY NO MATTER WHO IS INFECTED 2. May take several treatments and combing to collect eggs and dead parasites 3. Follow directions for application/removal
Antiparasitics: Black Box 1. Lowers seizure threshold 2. DO NOT APPLY TO WARM/IRRITATED SKIN 3. Multiple treatments may be needed 4. Hygiene/environment can prevent reinfestation
Antivirals: Examples and Uses Treatment for herpes, varicella, hepatitis = Zovirax (herpes), Adefovir, Famvir, Valtrex, Valacyclovir (IV slowly for herpes) - Tamiflu (influenza) - Ribavirin (RSV) - avoid alcohol - Viruses usually have to run its course (antivirals are NOT antibioti
Antivirals: Adverse reaction (besides nausea, vomiting, and diarrhea) 1. Anorexia 2. Rash 3. Headache 4. Orthostatic hypotension 5. Nephrotoxicity 6. Bone marrow suppression
Antivirals: Associated Labs 1. Renal (BUN, Cr) 2. Liver (ALT/AST)
Antivirals: Nursing Considerations Care is supportive in nature: based on signs, symptoms, severity
Antivirals: Patient Education 1. No unprotected sex while being treated 2. Increase fluids 3. Don gloves when applying ointment 4. Practice good hand hygiene
Antivirals: Black Box 1. Hydration = Key (prevents crystalluria and supports kidney function) 2. Most antivirals DO NOT CURE 3. Antivirals like Tamiflu are most effective when started within 48hrs of symptoms
Antiretrovirals (includes Protease Inhibitors/Reverse Transcriptase Agents): Example and Uses 1. Protease Inhibitors (PI) = Kaletra, Crixivan, Ritonavir 2. Reverse transcriptase inhibitor (RTI) = Combivir, Sustiva 3. Treats HIV/AIDS: works on RNA to prevent replication 4. HAART: Highly Active Antiretroviral Therapy = multiple agents at same tim
Antiretrovirals (includes Protease Inhibitors/Reverse Transcriptase Agents: Adverse reaction 1. Nausea, vomiting, diarrhea 2. Altered taste 3. Insulin resistance
Antiretrovirals (includes Protease Inhibitors/Reverse Transcriptase Agents): Associated Labs 1. Renal (BUN, Cr) 2. Liver (ALT/AST) 3. Viral load (200+ means AIDS/-200 means HIV) 4. CD4
Antiretrovirals (includes Protease Inhibitors/Reverse Transcriptase Agents): Nursing Considerations 1. Give 1hr before or 2hrs after Videx 2. Exacerbation of diabetes, immunosuppression, paresthesia 3. Anemia and spontaneous bleeding in the joints 4. Alterations in sleep = insomina/abnormal dreams
Antiretrovirals (includes Protease Inhibitors/Reverse Transcriptase Agents): Patient Education 1. No mixing with juice or acidic fluids and take with food 2. NO ALCOHOL 3. 48oz of fluids per day 4. DO NOT USE WITH ST. JOHN'S WORT 5. No antacids or iron unless physician cleared 6. Body fat redistribution 7. Decreases effectiveness of birth co
Antiretrovirals (includes Protease Inhibitors/Reverse Transcriptase Agents): Black Box 1. Monitor for signs of anemia/immunosuppression while taking 2. Sleep disturbances = common 3. Monitor glucose, especially with PI 4. Seperate dosing from Videx (1hr before or 2hrs after)
Anti-tubercular: Examples and Uses 1. Treats tuberculosis 2. Isoniazid (INH) is the only drug recommended for prophylactic treatment (recommended duration = 1 year) 3. DO NOT give to over 35 due to high incidence of hepatitis
Anti-tubercular: Nursing Considerations 1. DO NOT touch medication once opened 2. Pregnant women CANNOT treat those with TB (active or prophylactic) or chicken pox
Anti-tubercular (INH) Uses and Side effects: Uses: Prophylaxis and treatment Side effects: hepatitis, peripheral neuropathy, hallucinations, slurred speech, NVD
Anti-tubercular (INH) Special notes: 1. Avoid bananas, aged cheese, alcohol 2. Give with vitamin B6 to prevent neuropathy
Anti-tubercular (Rifampin): Uses and Side effects Uses: Active TB treatment Side effects: drowsiness, numbness, transient hearing loss, vision disturbances, possible lethargy/unconsciousness, vertigo, nausea, discoloration of body fluids (red/orange), bleeding
Anti-tubercular (Rifampin): Special notes: Do not wear contact lenses when receiving treatments and expect elevated glucose levels. Take on an empty stomach
Anti-tubercular (Ethambutol) Uses and Side effects: Uses: Active TB treatment Side effects: dizziness, headache, confusion, dermatitis, abdominal pain, anorexia, optic neuritis, vision loss/changes in color perception
Anti-tubercular (Ethambutol) Special notes: Baseline and regular eye exams required
Anti-tubercular (Pyrazinamide) Uses and Side effects: Uses: Active TB treatment Side effects: photosensitivity, liver damage, gout, decreased clotting time, anemia
Anti-tubercular (Pyrazinamide) Special notes: Monitor liver enzymes and uric acid levels
Anti-tubercular (Ethionamide) Uses and Side effects: Uses: 2nd line TB treatment Side effects: Postural hypotension, depression, jaundice, NVD
Anti-tubercular (Ethionamide) Special notes: Use caution in hepatic dysfunction
Anti-tubercular (Capreomycin) Uses and Side effects: Uses: 2nd line TB treatment Side effects: Headache, ototoxicity, nephrotoxicity, abnormal liver functions, macro-papular rash, urticaria, muscle weakness/swelling, sterile abscesses/excessive bleeding at injection site
Anti-tubercular (Capreomycin) Special notes: Monitor hearing and kidney function
TB treatment considerations: 1. Monitor liver function with TB therapy 2. May be isolated/court-ordered to complete TB therapy if non-compliant. 3. Report numbness, vision changes, persistent nausea, jaundice, easy bruising immediately 4. No PPD test after conversion (chest X-ray)
TB treatment patient education: 1. Take meds as prescribed (non-adherence = resistance) 2. DO NOT mix TB meds with others (includes topicals) 3. Avoid alcohol, aged cheese, bananas, fermented food 4. DO NOT touch meds once opened (gloves/tools) 5. Less effectiveness of birth control
Created by: dzanderia
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