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13 - Pharmacotherapy

Module 13 Pharmacotherapy

Generic nameDrug overview
sertraline Brand name: Zoloft Class: SSRI Indication: Depression Pearls: - ADRs of SSRIs include: GI disturbances, sleep disturbances, sexual dysfunction
fluoxetine Brand name: Prozac Class: SSRI Indication: Depression Pearls: - ADRs of SSRIs include: GI disturbances, sleep disturbances, sexual dysfunction
paroxetine Brand name: Paxil Class: SSRI Indication: Depression Pearls: - ADRs of SSRIs include: GI disturbances, sleep disturbances, sexual dysfunction
citalopram Brand name: Celexa Class: SSRI Indication: Depression Pearls: - ADRs of SSRIs include: GI disturbances, sleep disturbances, sexual dysfunction
escitalopram Brand name: Lexapro Class: SSRI Indication: Depression Pearls: - ADRs of SSRIs include: GI disturbances, sleep disturbances, sexual dysfunction
duloxetine Brand name: Cymbalta Class: SNRI Indication: Depression; neuropathic pain Pearls: - ADRs of SNRIs include: GI disturbances, sleep disturbances, sexual dysfunction
venlafaxine Brand name: Effexor Class: SNRI Indication: Depression Pearls: - ADRs of SNRIs include: GI disturbances, sleep disturbances, sexual dysfunction
desvenlafaxine Brand name: Pristiq Class: SNRI Indication: Depression Pearls: - ADRs of SNRIs include: GI disturbances, sleep disturbances, sexual dysfunction
amitriptyline Brand name: Elavil Class: TCA Indication: Depression; migraine prophylaxis Pearls: - ADR: Anticholinergic side effects (dry mouth, constipation, blurred vision) - Can cause sedation, often dosed at bedtime
nortriptyline Brand name: Pamelor Class: TCA Indication: Depression; migraine prophylaxis Pearls: - ADR: Anticholinergic side effects (dry mouth, constipation, blurred vision) - Can cause sedation, often dosed at bedtime
bupropion Brand name: Zyban; Wellbutrin Class: Norepinephrine/dopamine reuptake inhibitor Indication: Antidepressant; smoking cessation; ADHD Pearls: - IR and ER (Wellbutrin, Wellbutrin XL) used for depression/ADHD - SR (Zyban) used for smoking cessation
mirtazapine Brand name: Remeron Class: Atypical antidepressant Indication: Depression Pearls: - ADR: Sedation; weight gain - May be helpful in patients with poor appetite or insomnia
trazodone Brand name: Desyrel Class: Atypical antidepressant Indication: Depression; insomnia Pearls: - Causes sedation; commonly used off-label for sleep
phenelzine Brand name: Nardil Class: MAOI Indication: Treatment-resistant depression Pearls: - Dietary restriction: Avoid tyramine-rich foods (e.g., aged cheeses, cured meats, chocolate, wine) - Risk of hypertensive crisis - Many drug interactions
tranylcypromine Brand name: Parnate Class: MAOI Indication: Treatment-resistant depression Pearls: - Dietary restriction: Avoid tyramine-rich foods (e.g., aged cheeses, cured meats, chocolate, wine) - Risk of hypertensive crisis - Many drug interactions
isocarboxazid Brand name: Marplan Class: MAOI Indication: Treatment-resistant depression Pearls: - Dietary restriction: Avoid tyramine-rich foods (e.g., aged cheeses, cured meats, chocolate, wine) - Risk of hypertensive crisis - Many drug interactions
selegiline Brand name: Emsam Class: MAOI Indication: Treatment-resistant depression Pearls: - Dietary restriction: Avoid tyramine-rich foods (e.g., aged cheeses, cured meats, chocolate, wine) - Risk of hypertensive crisis - Many drug interactions
haloperidol Brand name: Haldol Class: Typical (first-generation) antipsychotic Indication: Schizophrenia Pearls: - High risk of extrapyramidal symptoms (EPS) (e.g., dystonia, akathisia, parkinsonism) - Benztropine is often prescribed to manage EPS
aripiprazole Brand name: Abilify Class: Atypical (second-generation) antipsychotic Indication: Schizophrenia Pearls: - Second-generation agents have a lower risk of EPS compared with first-generation - “-azole” suffix ≠ antifungal
clozapine Brand name: Clozaril Class: Atypical (second-generation) antipsychotic Indication: Treatment-resistant schizophrenia Pearls: - Risk of agranulocytosis; requires regular CBC monitoring; REMS program required
lurasidone Brand name: Latuda Class: Atypical (second-generation) antipsychotic Indication: Schizophrenia Pearls: - Second-generation agents have a lower risk of EPS compared with first-generation
olanzapine Brand name: Zyprexa Class: Atypical (second-generation) antipsychotic Indication: Schizophrenia Pearls: - ADR: Sedation, weight gain, hyperglycemia, and metabolic syndrome - Monitor weight, glucose, and lipids - LAI formulation has a REMS program
paliperidone Brand name: Invega Class: Atypical (second-generation) antipsychotic Indication: Schizophrenia Pearls: - Second-generation agents have a lower risk of EPS compared with first-generation
quetiapine Brand name: Seroquel Class: Atypical (second-generation) antipsychotic Indication: Schizophrenia Pearls: - Second-generation agents have a lower risk of EPS compared with first-generation - Causes sedation; often dosed at bedtime
risperidone Brand name: Risperdal Class: Atypical (second-generation) antipsychotic Indication: Schizophrenia Pearls: - Second-generation agents have a lower risk of EPS compared with first-generation
gabapentin Brand name: Neurontin Class: Anticonvulsant Indication: Epilepsy; nerve pain Pearls: - Often used for nerve pain, not effective for acute pain relief - Not a controlled substance at the federal level - Some states classify it as controlled
pregabalin Brand name: Lyrica Class: Anticonvulsant Indication: Epilepsy; nerve pain Pearls: - Often used for nerve pain, not effective for acute pain - DEA Schedule V
topiramate Brand name: Topamax Class: Anticonvulsant Indication: Epilepsy; migraine prophylaxis Pearls: - Often used to prevent migraines - Hazardous drug - Avoid in pregnancy (teratogenic)
divalproex Brand name: Depakote Class: Anticonvulsant Indication: Epilepsy Pearls: - Hazardous drug - Avoid in pregnancy (teratogenic)
phenytoin Brand name: Dilantin Class: Anticonvulsant Indication: Epilepsy Pearls: - Narrow therapeutic index (NTI) drug
lamotrigine Brand name: Lamictal Class: Anticonvulsant Indication: Epilepsy Pearls: - Risk of serious rash (Stevens–Johnson syndrome), especially with rapid dose escalation - Must be titrated slowly
levetiracetam Brand name: Keppra Class: Anticonvulsant Indication: Epilepsy Pearls:
Created by: pta78
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