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01 - Pharmacotherapy
Module 1 Pharmacotherapy
| Generic drug name | Drug overview |
|---|---|
| lisinopril | Brand name: Zestril; Prinivil Class: ACE Inhibitor Indication: Hypertension Pearls: - ACE inhibitors may cause a dry cough - ACE inhibitors are contraindicated in pregnancy |
| benazepril | Brand name: Lotensin Class: ACE Inhibitor Indication: Hypertension Pearls: - ACE inhibitors may cause a dry cough - ACE inhibitors are contraindicated in pregnancy |
| ramipril | Brand name: Altace Class: ACE Inhibitor Indication: Hypertension Pearls: - ACE inhibitors may cause a dry cough - ACE inhibitors are contraindicated in pregnancy |
| enalapril | Brand name: Vasotec Class: ACE Inhibitor Indication: Hypertension Pearls: - ACE inhibitors may cause a dry cough - ACE inhibitors are contraindicated in pregnancy |
| losartan | Brand name: Cozaar Class: ARB Indication: Hypertension Pearls: - Like ACE-I's, ARBs are also contraindicated in pregnancy - Unlike ACE-I's, ARBs do NOT cause cough |
| olmesartan | Brand name: Benicar Class: ARB Indication: Hypertension Pearls: - Like ACE-I's, ARBs are also contraindicated in pregnancy - Unlike ACE-I's, ARBs do NOT cause cough |
| irbesartan | Brand name: Avapro Class: ARB Indication: Hypertension Pearls: - Like ACE-I's, ARBs are also contraindicated in pregnancy - Unlike ACE-I's, ARBs do NOT cause cough |
| valsartan | Brand name: Diovan Class: ARB Indication: Hypertension Pearls: - Like ACE-I's, ARBs are also contraindicated in pregnancy - Unlike ACE-I's, ARBs do NOT cause cough |
| metoprolol tartrate | Brand name: Lopressor Class: Beta-blocker Indication: Hypertension; heart failure, arrhythmia Pearls: - Metoprolol tartrate is taken twice daily (as opposed to once daily for succinate) - Beta-blockers should be avoided in patients with asthma |
| metoprolol succinate | Brand name: Toprol XL Class: Beta-blocker Indication: Hypertension; heart failure, arrhythmia Pearls: - Metoprolol succinate is taken once daily (as opposed to twice daily for tartrate) - Beta-blockers should be avoided in patients with asthma |
| carvedilol | Brand name: Coreg Class: Beta-blocker Indication: Hypertension; heart failure, arrhythmia Pearls: - Beta-blockers should be avoided in patients with asthma - Take with food |
| atenolol | Brand name: Tenormin Class: Beta-blocker Indication: Hypertension; heart failure, arrhythmia Pearls: - Beta-blockers should be avoided in patients with asthma |
| labetalol | Brand name: Trandate Class: Beta-blocker Indication: Hypertension; heart failure, arrhythmia Pearls: - Beta-blockers should be avoided in patients with asthma |
| propranolol | Brand name: Inderal Class: Beta-blocker Indication: Hypertension; heart failure, arrhythmia Pearls: - Beta-blockers should be avoided in patients with asthma |
| amlodipine | Brand name: Norvasc Class: Calcium channel blocker (dihydropyridine) Indication: Hypertension Pearls: |
| nifedipine | Brand name: Procardia; Adalat Class: Calcium channel blocker (dihydropyridine) Indication: Hypertension Pearls: |
| diltiazem | Brand name: Cardizem Class: Calcium channel blocker (non-dihydropyridine) Indication: Hypertension Pearls: |
| verapamil | Brand name: Calan Class: Calcium channel blocker (non-dihydropyridine) Indication: Hypertension; atrial fibrillation Pearls: |
| hydrochlorothiazide | Brand name: Microzide Class: Thiazide diuretic Indication: Hypertension Pearls: - Common abbreviation: HCTZ - Diuretics are typically taken in the morning |
| chlorthalidone | Brand name: Zaroxolyn Class: Thiazide diuretic Indication: Hypertension Pearls: - Diuretics are typically taken in the morning |
| losartan / hydrochlorothiazide | Brand name: Hyzaar Class: Combination of ARB + Thiazide diuretic Indication: Hypertension Pearls: - Take in the morning (diuretic) - Avoid in pregnancy (ARB) |
| lisinopril / hydrochlorothiazide | Brand name: Zestoretic Class: Combination of ACE-I + Thiazide diuretic Indication: Hypertension Pearls: - Take in the morning (diuretic) - Avoid in pregnancy (ACE-I) |
| furosemide | Brand name: Lasix Class: Loop diuretic Indication: Hypertension Pearls: - Diuretics are typically taken in the morning - Can cause hypokalemia (low potassium). Many patients take a potassium supplement. |
| bumetanide | Brand name: Bumex Class: Loop diuretic Indication: Hypertension Pearls: - Diuretics are typically taken in the morning - Can cause hypokalemia (low potassium). Many patients take a potassium supplement. |
| torsemide | Brand name: Demadex Class: Loop diuretic Indication: Hypertension Pearls: - Diuretics are typically taken in the morning - Can cause hypokalemia (low potassium). Many patients take a potassium supplement. |
| spironolactone | Brand name: Aldactone Class: Potassium-sparing diuretic Indication: Hypertension Pearls: - Diuretics are typically taken in the morning - Can cause hyperkalemia (high potassium) - Avoid high-potassium foods and salt substitutes like Dash |
| triamterene / hydrochlorothiazide | Brand name: Dyazide Class: Potassium-sparing diuretic + thiazide diuretic Indication: Hypertension Pearls: - Diuretics are typically taken in the morning - ADR: hyperkalemia (high potassium) - Avoid high-potassium foods / salt substitutes like Dash |
| potassium chloride | Brand name: Klor-Con; K-Dur; K-Tab Class: Potassium supplement Indication: Prevent/treat hypokalemia Pearls: - Abbreviation: KCl - Replaces potassium lost from loop/thiazides - Available as: tabs, caps, powder, solution - Solution must be diluted |
| doxazosin | Brand name: Cardura Class: Alpha 1 blocker Indication: Hypertension; BPH Pearls: - ADR: Orthostatic hypotension. Patients should rise slowly from sitting or lying positions - Alpha 1 blockers can treat HTN, BPH, or both. Doxazosin treats both. |
| terazosin | Brand name: Hytrin Class: Alpha 1 blocker Indication: Hypertension; BPH Pearls: - ADR: Orthostatic hypotension. Patients should rise slowly from sitting or lying positions - Alpha 1 blockers can treat HTN, BPH, or both. Terazosin treats both. |
| prazosin | Brand name: Minipress Class: Alpha 1 blocker Indication: Hypertension Pearls: - ADR: Orthostatic hypotension. Patients should rise slowly from sitting/lying positions - Alpha 1 blockers can treat HTN, BPH, or both. Prazosin treats HTN only. |
| tamsulosin | Brand name: Flomax Class: Alpha 1 blocker Indication: BPH Pearls: - ADR: Orthostatic hypotension. Patients should rise slowly from sitting or lying positions - Alpha 1 blockers can treat HTN, BPH, or both. Tamsulosin treats BPH only. |
| hydralazine | Brand name: Apresoline Class: Peripheral vasodilator Indication: Hypertension Pearls: - ADR: orthostatic hypotension. Patients should rise slowly from sitting or lying positions |
| clonidine | Brand name: Catapress; Kapvay Class: Alpha 2 adrenergic agonist Indication: Hypertension; ADHD Pearls: - ADR: orthostatic hypotension. Patients should rise slowly from sitting or lying positions |
| aspirin | Brand name: Various Class: NSAID; Salicylate Indication: Antiplatelet (low dose); Analgesic/antipyretic (high dose) Pearls: - Low-dose "baby aspirin" should never be given to infants - ADR: Increased bleeding risk - Abbreviation: ASA |
| clopidogrel | Brand name: Brilinta Class: Antiplatelet Indication: Prevent blood clots Pearls: - ADR: Increased risk of bleeding |
| warfarin | Brand: Coumadin Class: Anticoagulant Indication: Prevent/treat clots Pearls: - Boxed warning: Risk of bleeding - Maintain consistent vitamin K intake - Antidote: Vitamin K (phytonadione) - Hazardous drug - Frequent blood monitoring / dose changes |
| apixaban | Brand name: Eliquis Class: Anticoagulant Indication: Prevent/treat blood clots Pearls: - ADR: Increased risk of bleeding |
| dabigatran | Brand name: Pradaxa Class: Anticoagulant Indication: Prevent/treat blood clots Pearls: - ADR: Increased risk of bleeding |
| enoxaparin | Brand name: Lovenox Class: Anticoagulant Indication: Prevent/treat blood clots Pearls: - ADR: Increased risk of bleeding - Administered via injection |
| rivaroxaban | Brand name: Xarelto Class: Anticoagulant Indication: Prevent/treat blood clots Pearls: - ADR: Increased risk of bleeding |
| nitroglycerin sublingual | Brand name: Nitro-Quick; Nitro-Stat Class: Vasodilator Indication: Angina Pearls: - SL tablet or spray. - Use 1 dose q 5 min PRN for up to 3 doses. Call 911 if no relief - DDI: PDE5-inhibitors (sildenafil, tadalafil) - Store in original container |
| isosorbide / hydralazine | Brand name: BiDil Class: Vasodilator Indication: Prevents angina (heart pain) Pearls: - DDI: PDE5-inhibitors (sildenafil, tadalafil etc.) Administering together may lead to heart attack or stroke. |
| digoxin | Brand name: Lanoxin; Digitek Class: Cardiac glycoside Indication: Heart failure; arrhythmia Pearls: - Narrow therapeutic index drug |