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autonomic drugs UCI

QuestionAnswer
epinephrine a1, a2, b2, b3, low doses selective for b1; anaphylaxis, glaucoma, asthma, hypotension
NE a1, a2>b1; hypotenstion with decreased renal perusion
Isoproterenol b1=b2; AV block
Dopamine D1=D2>b>a, inotropic and chronotropic; shock, heart failure
Dobutamine b1>b2, inotropic not chronotropic; shock, heart failure, cardiac stress testing
Phenylephrine =methoxamine, a1>a2; pupillary dilation, vasoconstriction, nasal congestion
Methoxamin =phenylephrine; a1>a2; pupillary dilation, vasoconstriction, nasal congestion
Albuterol b2>b1; acute asthma
terbutaline b2>b1; reduces premature uterine contractions
ritodrine =metaproterenol; b2 reduces premature uterine contractions
metaproterenol =ritodrine; b2 reduces premature uterine contractions
amphetamine releases stored catecholamines; narcolepsy, obesity, ADD
ephedrine =tyramine; releases stored catecholamines; nasal decongestion, urinary incontinence, hypotension
tyramine =ephedrine; releases stored catecholamines; nasal decongestion, urinary incontinence, hypotension
cocaine uptake inhibitor; causes vasoconstriction and local anesthesia
clonadine =a-methyldopa; a2 agonist; hypertension with renal disease (no decrease in renal blood flow), glaucoma, sedation
a-methyldopa =clonadine; a2 agonist; hypertension with renal disease (no decrease in renal blood flow)
guanfacine =clonidine, brimonidine, dexmadetomidine; a2 agonist; hypertension with renal disease (no decrease in renal blood flow), glaucoma, sedation
brimonidine =clonidine, guanficine, dexmedetomidine; a2 agonist; hypertension with renal disease (no decrease in renal blood flow), glaucoma, sedation
dexmedetomidine =clonidine, guanfacine, brimonidine; a2 agonist; hypertension with renal disease (no decrease in renal blood flow), glaucoma, sedation
b2 agonists MAST; metaproterenol, albuterol, salmeterol, terbutaline
phenoxybenzamine irreversible a-blocker; for pheochromocytoma tumor removal; toxic-orthostatic hypotenstion, reflex tachycardia
phentolamine reversible a-blocker; for pheochromocytoma tumor removal; toxic-orthostatic hypotenstion, reflex tachycardia
prazosin =terazosin, doxazosin;a1-blocker; for htn, urinary retention in BPH; toxic-orthostatic hypotenstion, dizziness, headache, cardiac problems
terazosin =prazosin, doxazosin; a1-blocker; for htn, urinary retention in BPH; toxic-orthostatic hypotenstion, dizziness, headache, cardiac problems
doxazosin =prazosin, terazosin; a1-blocker; for htn, urinary retention in BPH; toxic-orthostatic hypotenstion, dizziness, headache, cardiac problems
mirtazapine a2 blocker; for depression; toxic- sedation, increased serum cholesterol and appetite
nonselective b-blockers propranolol, timolol, nadolol, pindolol, labetalol
b1 blockers A BEAM; acebutolol, betaxolol, esmolol, atenolol, metoprolol
b blocker application HTN (lower CO ad renin), angina pectoris, thyroid storm, migraine, anxiety, MI, SVT, CHF, glaucoma (decreased secretion
b blocker toxicity impotence, worse asthma, CV problems, hypoglycemia, b-receptor hypersensitivity, sedation, sleep alterations
a-methyl-para-tyrosine inhibits tyrosine hydroxylase
reserpine binds VMAT 1+2 depleting catecholamine stores (obsolete)
tetrabenzine binds VMAT 2 (for Huntington’s chorea)
guanethidine displaces NE in storage granules; no BBB; receptor hypersensitivity; for HTN
imipramine =amitryptiline; potentiate direct acting, inhibit indirect acting sympatomimetics
amitryptiline =imipramine; potentiate direct acting, inhibit indirect acting sympatomimetics
isocarboxiazide ==tranylcypromine; MAO inhibitor, for depression and parkinson's
tranylcypromine =isocarboxiazide; MAO inhibitor, for depression and parkinson's
cevimeline =pilocarpine; cholinomimetic; stimulates sweat, tears, saliva; used for glaucoma among others
methacholine asthma challenge test; cholinomimetic
neostigmine anticholinesterase; postoperative and neurogenic ileus and urinary retention, myesthenia gravis, reversal of neuromuscular junction blockade
pyridostigmine =ambenonium; myasthenia gravis
ambenonium =pyridostigmine; myasthenia gravis
edrophonium diagnose myasthenia gravis
physostigmine glaucoma and atropine overdose and to increase bowel/bladder motility
echothiophate irreversible anticholinesterase; glaucoma
galantamine =rivastigmine, donepazil, tacrine; anticholinesterase; alzheimer 1st line
rivastigmine =galantamine, donepazil, tacrine; anticholinesterase; alzheimer 1st line
donepazil =galantamine, rivastigmine, tacrine; anticholinesterase; alzheimer 1st line
tacrine =galantamine, rivastigmine, donepazil; anticholinesterase; alzheimer 1st line
cholinesterase inhibitor poisoning DUMBBELSS: diarrhea, urination, miosis, bronchospas, bradycardia, excitation of skeletal muscle and CNS, lacrimation, sweating, salivation
antidote to anticholinesterase poisoning atropine plus pralidoxime (ZPAM)
parathion =malathione; insectiside and anticholinesterase
malathione =parathione; insectiside and anticholinesterase
isofluorophate (DFP) anticholinesterase; inactivates AchE for days to weeks by phosphorylation
atropine =homatropine, tropicamide; produce mydriasis and cycloplegia; blocks DUMBBELSS
homatropine =atropine, tropicamine; produce mydriasis and cycloplegia
tropicamine = atroopine, homatropine; produce mydriasis and cycloplegia
benztropine muscarinic antogonist; parkinson's
scopalamine muscarinic antagonist; motion sickness and short term memory loss
ipratropium =tiotropium; asthma, COPD; muscarinic antagonist
triotropium =ipratropium; asthma, COPD; muscarinic antagonist
oxybutynin =glycopyrrolate, clidum; muscarinic antagonist; reduce urgency in cystitis and reduce bladder spasms
glycopyrrolate =oxybutynin, clidium; muscarinic antagonist; reduce urgency in cystits and reduce bladder spasms
clidium =oxybutynin, glycopyrrolate; muscarinic antagonist; reduce urgency in cystitis and reduce bladder spasms
tolterodine urinary incontinence in elderly; enuresis in kids; muscarinic antagonist
methscopalamine =pirenzepine, propantheline; muscarinic antagonist; peptic ulcer treatment
pirenzepine =methscopalamine, propantheline; muscarinic antagonist; peptic ulcer treatments
propantheline =methscopalamine, pirenzepine; muscarinic antagonist; peptic ulcer treatments
hexamethonium nicotinic antagonist
Created by: droid
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