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CNS 2
| Pharmacological Category | Generic | Brand | Classification | Common Indication | Key side effects | US boxed warnings | Other notes |
|---|---|---|---|---|---|---|---|
| CNS stimulant | dexmethylphenidate (PO) | Focalin, Focalin XR | CS-II | ADHD | insomnia, headache, anxiety, weight loss, decreased appetite, hypertension | high potential for abuse | CI within 14 days of MAOI |
| CNS stimulant | dextroamphetamine and amphetamine (PO) | Adderall, Adderall XR | CS-II | ADHD, narcolepsy | insomnia, headache, anxiety, weight loss, decreased appetite, hypertension | high potential for abuse | CI within 14 days of MAOI |
| CNS stimulant | lisdexamfetamine (PO) | Vyvanse | CS-II | ADHD | insomnia, headache, anxiety, weight loss, decreased appetite, hypertension | high potential for abuse | CI within 14 days of MAOI |
| CNS stimulant | methylphenidate (PO, transdermal) | PO: Concerta, Ritalin Patch: Daytrana | CS-II | ADHD, narcolepsy | insomnia, headache, anxiety, weight loss, decreased appetite, hypertension | high potential for abuse | CI within 14 days of MAOI |
| Selective alpha2a agonist | guanfacine (PO) | Intuniv | n/a | ADHD, HTN | bradycardia, hypotension, sedation, skin rash, xerostomia, constipation | n/a | do not abruptly discontinue |
| Dopamine agonist | pramipexole (PO) | Mirapex | n/a | Parkinson's disease, RLS | nausea, hallucinations, dizziness, drowsiness, compulsive behaviors, orthostasis | n/a | n/a |
| Dopamine agonist | ropinirole (PO) | Requip | n/a | Parkinson's disease, RLS | nausea, hallucinations, dizziness, drowsiness, compulsive behaviors, orthostasis | n/a | n/a |
| Decarboxylase inhibitor (carbidopa), dopamine precursor (levodopa) | carbidopa and levodopa (PO) | Sinemet, Sinemet CR | n/a | Parkinson's disease | nausea, orthostatic hypotension, dyskinesias | n/a | CI within 14 days of MAOI, CI in narrow-angle glaucoma; do not abruptly discontinue |
| N-methyl D- aspartate (NMDA) antagonist | memantine (PO) | Namenda | n/a | Dementia | constipation, confusion, dizziness, headache | n/a | n/a |
| Cholinesterase inhibitor | donepezil (PO, transdermal) | PO: Aricept, Transdermal: Adlarity | n/a | Dementia | nausea, vomiting, diarrhea | n/a | n/a |