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CNS 1

Pharmacological categoryGenericBrand Common IndicationKey Side effectsUS boxed warningsOther notes
Alpha2 antagonist mirtazapine (PO) Remeron MDD drowsiness, weight gain, xerostomia, increased appetite, constipation increased risk of suicidal thinking and behavior in children, adolescents, and young adults n/a
Norepinephrine- dopamine reuptake inhibitor bupropion (PO) Wellbutrin SR, Wellbutrin XL MDD tachycardia, headache, agitation, dizziness, insomnia, weight loss, xerostomia increased risk of suicidal thinking and behavior in children, adolescents, and young adults; serious neuropsychiatric reactions have occurred use may increase risk of seizures (CI in patients with seizure disorders and/or eating disorders)
Selective norepinephrine reuptake inhibitor atomoxetine (PO) Strattera ADHD hypertension, tachycardia, headache, xerostomia, nausea, vomiting, constipation, decreased appetite, insomnia increased risk of suicidal ideation in children or adolescents CI within 14 days of MAOI
Serotonin- norepinephrine reuptake inhibitor (SNRI) desvenlafaxine (PO) Pristiq MDD headache, xerostomia, nausea, vomiting, constipation, decreased appetite, insomnia. diaphoresis, hypertension, sexual dysfunction increased risk of suicidal thinking and behavior in children, adolescents, and young adults CI within 14 days of MAOI; do not discontinue abruptly
Serotonin- norepinephrine reuptake inhibitor (SNRI) duloxetine (PO) Cymbalta MDD, neuropathic pain headache, xerostomia, nausea, vomiting, constipation, decreased appetite, insomnia. diaphoresis, hypertension, sexual dysfunction increased risk of suicidal thinking and behavior in children, adolescents, and young adults CI within 14 days of MAOI; do not discontinue abruptly
Serotonin- norepinephrine reuptake inhibitor (SNRI) venlafaxine (PO) Effexor XR MDD headache, xerostomia, nausea, vomiting, constipation, decreased appetite, insomnia. diaphoresis, hypertension, sexual dysfunction increased risk of suicidal thinking and behavior in children, adolescents, and young adults CI within 14 days of MAOI; do not discontinue abruptly
Selective serotonin reuptake inhibitor (SSRI) citalopram (PO) Celexa MDD drowsiness, insomnia, nausea, vomiting, xerostomia, sexual dysfunction, headache, diaphoresis increased risk of suicidal thinking and behavior in children, adolescents, and young adults CI within 14 days of MAOI; do not discontinue abruptly (all except fluoxetine)
Selective serotonin reuptake inhibitor (SSRI) fluoxetine (PO) Prozac MDD drowsiness, insomnia, nausea, vomiting, xerostomia, sexual dysfunction, headache, diaphoresis increased risk of suicidal thinking and behavior in children, adolescents, and young adults CI within 14 days of MAOI; do not discontinue abruptly (all except fluoxetine)
Selective serotonin reuptake inhibitor (SSRI) escitalopram (PO) Lexapro MDD drowsiness, insomnia, nausea, vomiting, xerostomia, sexual dysfunction, headache, diaphoresis increased risk of suicidal thinking and behavior in children, adolescents, and young adults CI within 14 days of MAOI; do not discontinue abruptly (all except fluoxetine)
Selective serotonin reuptake inhibitor (SSRI) paroxetine (PO) Paxil MDD drowsiness, insomnia, nausea, vomiting, xerostomia, sexual dysfunction, headache, diaphoresis increased risk of suicidal thinking and behavior in children, adolescents, and young adults CI within 14 days of MAOI; do not discontinue abruptly (all except fluoxetine)
Selective serotonin reuptake inhibitor (SSRI) sertraline (PO) Zoloft MDD drowsiness, insomnia, nausea, vomiting, xerostomia, sexual dysfunction, headache, diaphoresis increased risk of suicidal thinking and behavior in children, adolescents, and young adults CI within 14 days of MAOI; do not discontinue abruptly (all except fluoxetine)
Serotonin reuptake inhibitor trazodone (PO) Desyrel Insomnia, MDD sedation, headache, dizziness, xerostomia, nausea, priapism increased risk of suicidal thinking and behavior in children, adolescents and young adults n/a
Tricyclic antidepressant (TCA) amitriptyline (PO) Elavil MDD, diabetic neuropathy, migraine prophylaxis dizziness, drowsiness, orthostatic hypotension, sexual dysfunction, xerostomia, blurred vision, constipation increased risk of suicidal thinking and behavior in children, adolescents, and young adults CI within 14 days of MAOI; do not discontinue abruptly
Tricyclic antidepressant (TCA) nortriptyline (PO) Pamelor MDD, diabetic neuropathy, migraine prophylaxis dizziness, drowsiness, orthostatic hypotension, sexual dysfunction, xerostomia, blurred vision, constipation increased risk of suicidal thinking and behavior in children, adolescents, and young adults CI within 14 days of MAOI; do not discontinue abruptly
Tricyclic antidepressant (TCA) doxepin (PO) Silenor Insomnia somnolence, sedation, nausea increased risk of suicidal thinking and behavior in children, adolescents, and young adults CI within 14 days of MAOI; do not discontinue abruptly
Created by: ziad5
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