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Pain, Hema, & Onco 3
| Pharmacologic Category | Generic Name | Brand Name | Classification | ||
|---|---|---|---|---|---|
| Antimetabolite (folic acid antagonist) | methotrexate (PO, IV, IT) | Trexall | Rheumatoid arthritis, Crohn’s Disease, psoriasis, various hematologic and solid tumors | Key Side Effects: stomatitis, diarrhea, nausea, vomiting, thrombocytopenia, leukopenia US Boxed Warnings: serious toxic reactions may cause fetal death and/or congenital abnormalities; severe bone marrow suppression, aplastic anemia, have been reported | |
| Antineoplastic agent, platinum- based compound | cisplatin (IV, IT, IP) | Kemoplat | Advanced bladder, ovarian, and testicular cancer; various cancers | Key Side Effects: bone marrow suppression, nausea, vomiting, nephrotoxicity, neurotoxicity, ototoxicity US Boxed Warnings: may cause severe myelosuppression, nausea and vomiting, renal toxicity, and dose-related neuropathy | |
| Antineoplastic agent, anthracycline | doxorubicin (IV) | Adriamycin | Adjuvant therapy for breast cancer, various cancers | Key Side Effects: cardiomyopathy, alopecia, nausea, vomiting, bone marrow suppression US Boxed Warnings: may cause cardiomyopathy, myelosuppression, secondary malignancies; extravasation can result in severe local tissue injury and necrosis Other Notes: | |
| Antineoplastic agent, monoclonal antibody | pembrolizumab (IV) | Keytruda | Various cancers | Key Side Effects: peripheral edema, pruritus, skin rash, endocrine and metabolic abnormalities, constipation, diarrhea, nausea, vomiting, hematuria, anemia, increased liver enzymes, fatigue, musculoskeletal pain, increased serum creatinine, dyspnea | |
| Aromatase inhibitor | anastrozole (PO) | Arimidex | Hormone receptor-positive breast cancer | Key Side Effects: fatigue, rash, flushing, hot flashes, arthralgia, nausea, vomiting, hypertension, peripheral edema, osteoporosis Other Notes: cardiovascular side effects (i.e., hypercholesterolemia, CAD); fetal toxicity (CI in pregnancy) | |
| Selective estrogen receptor modulator (SERM) | tamoxifen (PO) | Soltamox | Hormone receptor-positive breast cancer | Key Side Effects: hot flashes/night sweats, vaginal bleeding/discharge, decreased bone density (in premenopausal females) US Boxed Warnings: increased risk for uterine or endometrial cancer and thromboembolic events Other Notes: contraception should be |
Created by:
kimchii
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