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BDK PHO #3
Basic Drug Knowledge Pain, Hematology, and Oncology Page #3
| Generic Name | Brand Name | Pharmacologic Category | Common Indications | Key Side Effects | US Boxed Warnings | US Boxed Warnings Cont. | US Boxed Warnings Cont. | Other Notes |
|---|---|---|---|---|---|---|---|---|
| Methotrexate (PO, IV, IT [Intrathecal]) | Trexall | Antimetabolite (Folic Acid Antagonist) | Rheumatoid Arthritis (RA), Crohn's disease, Psoriasis, Various Hematologic and Solid Tumors | Stomatitis, Diarrhea, Nausea, Vomiting, Thrombocytopenia, Leukopenia, Increased Hepatic Transaminases, Pulmonary Fibrosis (Rare) | Serious toxic reactions (only use in life-threatening neoplastic disease, severe psoriasis, or severe rheumatoid arthritis); May cause fetal death or congenital abnormalities (avoid in pregnancy); Severe (sometimes fatal) bone | marrow suppression, aplastic anemia, & toxicity have been reported with concomitant administration of methotrexate & NSAIDs; May cause hepatotoxicity; Methotrexate-induced lung disease, including acute or chronic interstitial pneumonitis; | Severe (sometimes fatal) GI toxicity has been reported with concomitant administration with NSAIDs; Hypersensitivity; For IT & high-dose therapy, use preservative-free formulation (may cause CNS toxicity or metabolic acidosis) | Folic acid supplementation may be taken during use to reduce hematologic, gastrointestinal, and hepatic side effects |
| Cisplatin (IV, IT [Intrathecal], IP [Intraperitoneal]) | Kemoplat | Antineoplastic Agent, Platinum-Based Compound | Advanced Bladder, Ovarian, and Testicular Cancer; Various Cancers | Bone Marrow Suprression, Nausea/Vomiting, Nephrotoxicity, Neurotoxicity, Ototoxicity | May cause severe myelosuppression severe nausea/vomiting (requires highly effective antiemetic premedication), renal toxicity, & dose-related neuropathy | |||
| Doxorubicin (IV) | Adriamycin | Antineoplastic Agent, Anthracycline | Adjuvant Therapy for Breast Cancer, Various Cancers | Cardiomyopathy, Alopecia, Nausea, Vomiting, Bone Marrow Suppression | May cause cardiomyopathy, myelosuppression, secondary malignancies; Extravasation can result in severe local tissue injury & necrosis | May cause red discoloration of urine, tears, sweat, & saliva | ||
| Pembrolizumab (IV), Pembrolizumab/Berahyaluronidase Alfa-Pmph (SC) | Keytruda (IV), Keytruda Qlex (SC) | Antineoplastic Agent, Monoclonal Antibody | Various Cancers | Peripheral Edema, Immune-Related Adverse Events (Including Pruritus, Skin Rash, Endocrine & Metabolic Abnormalities, Diarrhea, Increased Liver Enzymes, Increased Serum Creatinine, Dyspnea), Nausea, Vomiting, Hematuria, Anemia, Faigue, Musculoskeletal Pain | ||||
| Anastrozole (PO) | Arimidex | Aromatase Inhibitor | Hormone Receptor-Positive Breast Cancer | Fatigue, Rash, Flushing, Hot Flashes, Arthralgia, Nausea, Vomiting, Hypertension, Peripheral Edema, Osteoporosis | Cardiovascular side effects (i.e., hypercholesterolemia, CAD); Fetal toxicity (CI in pregnancy) | |||
| Tamoxifen (PO) | Soltamox | Selective Estrogen Receptor Modulator (SERM) | Hormone Receptor-Positive Breast Cancer | Hot Flashes/Night Sweas, Vaginal Bleeding/Discharge, Decreased Bone Density (in Premenopausal Females) | Increased risk for uterine or endometrial cancer & thromboembolic events | Contraception should be used in premenopausal females due to teratogenicity of the drug; Do not use with warfarin or history DVT/PE (Deep Vein Thrombosis/Pulmonary Embolism) |
Created by:
nataliemvo
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