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Endocrine 3
| Pharm. Category | Generic | Brand | Common Indication | Essential Knowledge | Other Notes |
|---|---|---|---|---|---|
| Androgen | testosterone gel (topical) | Androgel, Fortesta, Vogelxo (CS-III) | Male hypogonaism | KSE: contact dermatitis, acne, increased prostate specific antigen, emotional lability, hypertension USBW: 2nd exposure may result in virilization (especially in children) | CI in males with breast or prostate cancer and pregnant women; apply in the morning |
| Bisphosphonate | alendronate (PO) | Fosamax | Osteoporosis | dyspepsia, gastroesophageal reflux disease, hypocalcemia, atypical fractures, osteonecrosis of the jaw | CI in patients q/ hypocalcemia, or abnormalities of the esophagus; administer >30 minutes before food or drink (except plain eater); remain upright for 30 min. following dose to reduce esophageal irritation |
| Vitamin D analog | cholecalciferol (vitamin D3) (PO) (OTC) | --- | Dietary supplement, osteoporosis prevention | vitamin D toxicity (nausea, vomiting, loss of appetite, constipation, confusion, weakness) | CI w/ hypercalcemia |
| Phosphodiesterase-5 enzyme (PDE5) inhibitor | sildenafil (PO) | Viagra, Revatio | ED, PAH | priapism, headache, flushing, visual disturbance, dyspepsia, hearing or vision loss (rare) | CI w/ concomitant use of nitrates (may cause severe hypotension) |
| Phosphodiesterase-5 enzyme (PDE5) inhibitor | tadalafil (PO) | Cialis, Adcirca | ED, BPH, PAH | priapism, headache, flushing, visual disturbance, dyspepsia, back pain, hearing or vision loss (rare) | CI w/ concomitant use of nitrates (may cause severe hypotension) |
| Thyroid product | levothyroxine (PO) | Synthroid, Levoxyl, Unithroid | Hypothyroidism | weigh loss, palpitations, diarrhea, insomnia, heat intolerance USBW: no intended for use of weight loss | Narrow therapeutic index drug (therapeutic monitoring is recommended); not all generic products are therapeutically equivalent |
| Thyroid product | thyroid, desiccated (PO) | Armour Thyroid | Hypothyroidism | weight loss, palpitations, diarrhea, insomnia, heat intolerance USBW: not intended for use for weight loss | Narrow therapeutic index drug (therapeutic monitoring is recommended); not all generic products are therapeutically equivalent |
| CNS Stimulant, anorexant | phentermine (PO) | Adipex-P | Obesity | tachycardia, hypertension, nausea, dizziness, xerostomia, agitation | only approved for short-term use; CI in those w/ a history of cardiovascular disease or drug abuse, pregnancy, hyperthyroidism, or within 14 days of MAOI therapy |
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