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Pain, Hema, Onc 1

Pharmacologic CategoryGenericBrandClassificationCommon IndicationKey Side effectsUS Boxed warningOther notes
Opioid analgesic fentanyl (transdermal, IV) Transdermal: Duragesic, IV: Sublimaze CS-II Pain dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) (see BDK for the rest) potential for medication errors when converting between dosage forms; use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase fentanyl concentrations; avoid exposing transdermal patch to external heat n/a
Opioid analgesic hydromorphone (PO, IV) Dilaudid CS-II Pain dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) (see BDK for the rest) risk of medication errors with high-potency hydromorphone, use in opioid-tolerant patients only n/a
Opioid analgesic morphine (extended release) (PO) MS Contin, Kadian CS-II Pain dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) (see BDK for the rest) coingestion with alcohol may result in potentially fatal overdose of morphine n/a
Opioid analgesic morphine (immediate release) (PO, IV, IM, PR) IV: Duramorph, Infumorph CS-II Pain dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) See BDK for big US boxed warning n/a
Opioid analgesic oxycodone (PO) OxyContin, Roxicodone CS-II Pain dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) (see BDK for the rest) use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase oxycodone concentrations n/a
Opioid analgesic methadone (PO, IV) Dolophine CS-II Opioid use disorder, severe chronic pain dizziness, drowsiness, nausea, vomiting, constipation, respiratory depression (dose-related), QTc prolongation (see BDK for the rest) QTc interval prolongation and serious arrhythmia (Torsades de Pointes) have occurred during treatment; concomitant use with CYP3A4, 2B6, 2C19, or 2D6 (or stopping the same inducers) can increase methadone concentrations n/a
Analgesic (non- opioid), antipyretic acetaminophen (PO, PR, IV) PO/PR: Tylenol, IV: Ofirmev PO, PR: OTC Pain, fever nausea, vomiting, increased hepatic transaminases total daily dose from all sources should not exceed maximum daily limit; hepatotoxicity n/a
Central analgesic; partial opioid agonist tramadol (PO) Ultram, Ultram ER CS-IV Pain dizziness, drowsiness, nausea, vomiting, constipation, respiratory depression (dose-related) see BDK List for Paragraph lowers seizure threshold
Created by: ziad5
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