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Pain,Hem, Oncology 2
| Generic | Brand | Category | Indication | EK | EK + |
|---|---|---|---|---|---|
| hydrocodone and acetaminophen (PO) | Lortab, Vicodin, Norco | Opioid and nonopioid analgesic combination | Pain | Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) | US Boxed Warnings (all opioid analgesics): See above US Boxed Warnings: use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase oxycodone concentrations; hepatotoxicity |
| oxycodone and acetaminophen (PO | Percocet, Endocet | Opioid and nonopioid analgesic combination | Pain | Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) | US Boxed Warnings (all opioid analgesics): See above US Boxed Warnings: use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase oxycodone concentrations; hepatotoxicity |
| codeine and acetaminophen (PO) | Tylenol with Codeine #3, Tylenol with Codeine #4 | Opioid and nonopioid analgesic combination | Pain | Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) | US Boxed Warnings: use or discontinuation of CYP3A4 inducers/inhibitors or 2D6 inhibitors requires caution; may alter codeine levels and ↑ toxicity risk; respiratory depression and death in ultra-rapid metabolizer children; risk of hepatotoxicity. |
| naloxone (IV, IM, SQ, intranasal) | Narcan Nasal Spray, Zimhi | Opioid antagonist | Opioid overdose | Key Side Effects: opioid withdrawal syndrome in opioid-dependent populations, pain | |
| buprenorphine and naloxone (SL) | Suboxone | Partial opioid agonist and opioid antagonist | Opioid use disorder | Key Side Effects: opioid withdrawal syndrome in opioid-dependent populations, constipation, headache, diaphoresis | Other Notes: life-threatening respiratory depression may occur when combined with CNS or respiratory depressants; adding naloxone to buprenorphine lowers misuse risk by causing opioid withdrawal if injected. |
| ferrous sulfate (PO) | FeroSul | Iron supplement | Iron deficiency anemia | Key Side Effects: nausea, stomach upset, constipation (dose-related), dark and tarry stools | US Boxed Warning: accidental overdose of iron is leading cause of fatal poisoning in children under 6 years old |
| cyanocobalamin (vitamin B12) (PO, IM, SL, intranasal) | B-12 | Water-soluble vitamin | Vitamin B12 deficiency (manifests as macrocytic anemia) | Key Side Effects: no major side effects | |
| folic acid (PO) | FA | Water-soluble vitamin | Folic acid deficiency (manifests as macrocytic anemia), prevention of neural tube defects in pregnancy | Key Side Effects: no major side effects |