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Ch 2
Definitions
| Question | Answer |
|---|---|
| Low dose-effect curve | measuring the response to the dose of the drug |
| potency | the amount of drug required to produce an effect |
| efficacy | related to the maximal effect of a drug regardless of dose |
| therapeutic action/effect | the intended or desired result |
| therapeutic range | range between the dose causing the minimum effect and the dose causing the minimum adverse effect |
| therapeutic index (TI) | number that determines the safety of a drug. (the greater the TI, the safer the drug) |
| efficacy | is the maximum intensity of effect or response that can be produced by a drug |
| renal | kidney |
| hepatic | liver |
| biotransformation | is the body's way of changing a drug so that it can be more easily excreted by the kidneys |
| tolerance | the need for an increasingly larger dose of the drug to obtain the same effects as original dose |
| duration | is the length of a drug's effect |
| half-life | the half-life of a drug is the amount of time that passes for its concentration to fall to half (50%) of its original blood level |
| median effect dose (ED50) | is the dose required to produce a desired clinical effect in 50% of test subjects. a low effective dose is preferred because it means less drug is needed to achieve the desired therapeutic effect |
| lethal dose (LD50) | is the amount of a substance that causes death in 50% of a test population. a lower LD means the substance is more toxic |
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