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DEENT 2
| Pharamcologic Category | Generic | Brand | Classification | Indication | Key Side Effects | US Boxed Warning | Other notes |
|---|---|---|---|---|---|---|---|
| Alpha (α1) agonist | pseudoephedrine (PO) | Sudafed | OTC | Nasal congestion | Increased blood pressure, tachycardia, palpitations, insomnia, restlessness | n/a | sold behind the counter, avoid during first trimester of pregnancy |
| Corticosteroid | fluticasone (intranasal) | Flonase | OTC | Allergic rhinitis | nasal dryness, epistaxis, nasal burning, headache | n/a | n/a |
| Corticosteroid | triamcinolone (intranasal) | Nasacort | OTC | Allergic rhinitis | nasal dryness, epistaxis, nasal burning, headache | n/a | n/a |
| Histamine (H1) blocker | azelastine (intranasal) | Astepro | OTC | Allergic rhinitis | headache, nasal dryness, epistaxis, bitter taste, drowsiness | n/a | n/a |
| Histamine (H1) blocker | diphenhydramine (PO, IV) | Benadryl | PO: OTC | Allergic rhinitis, allergic reaction, insomnia | drowsiness, constipation, xerostomia, urinary retention, cognitive impairment | n/a | for OTC use, do NOT use in children < 6 years of age |
| Histamine (H1) blocker | hydroxyzine (PO, IV) | Atarax, Vistaril | n/a | Pruritus, nausea, anxiety | dizziness, somnolence, xerostomia, blurred vision, QTc prolongation | n/a | n/a |
| Histamine (H1) blocker | cetirizine (PO) | Zyrtec | OTC | Allergic rhinitis | drowsiness, dizziness, headache | n/a | n/a |
| Histamine (H1) blocker | loratadine (PO) | Claritin | OTC | Allergic rhinitis | drowsiness, dizziness, headache | n/a | n/a |
| Histamine (H1) blocker | fexofenadine (PO) | Allegra | OTC | Allergic rhinitis | drowsiness, dizziness, headache | n/a | n/a |
| Histamine (H1) blocker | levocetirizine (PO) | Xyzal | OTC | Allergic rhinitis | diarrhea, drowsiness, headache | n/a | n/a |
| Histamine (H1) blocker | olopatadine (ophthalmic) | Pataday, Patanol | OTC | Allergic conjunctivitis | ocular burning, discomfort, dryness | n/a | n/a |
| Histamine (H1) blocker and opioid analgesic | promethazine and codeine (PO) | Phenergan with Codeine | CS-V | Cough | dizziness, somnolence, xerostomia, blurred vision, constipation, respiratory depression (dose-related) | concomitant use of opioids with benzodiazepines or other CNS depressants (including alcohol), may result in profound sedation, respiratory depression, coma, and death | opioid-containing cough and cold products no longer indicated for use in patients <18 years of age |
| Opioid analgesic and expectorant | codeine and guaifenesin (PO) | Robitussin AC, Cheratussin AC | CS-V | Cough | dizziness, somnolence, constipation, respiratory depression (dose-related) | n/a | opioid-containing cough and cold products no longer indicated for use in patients <18 years of age |