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BDK Musculoskeletal

Basic Drug Knowledge Musculoskeletal

Generic NameBrand NameClassificationPharmacologic CategoryCommon IndicationsKey Side EffectsUS Boxed WarningsUS Boxed Warnings Cont.Other Notes
Tizanidine (PO) Zanaflex Alpha 2 Agonist Spasticity Drowsiness, Hypotension, Dizziness, Xerostomia, Weakness
Hydroxychloroquine (PO) Plaquenil Aminoquinolone Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), Malaria Retinal Toxicity, Rash, Diarrhea Long-term use has been associated with cardiomyopathy, Bone marrow suppression, QT prolongation, & Neuromuscular effects (i.e., Myopathy, Palsies, & Progressive weakness)
Diclofenac (Topical) Voltaren Gel OTC Non-Steroidal Anti-Inflammatory Drug (NSAID) Osteoarthritis (OA) Pruritus, Rash
Diclofenac (PO) Voltaren Non-Steroidal Anti-Inflammatory Drug (NSAID) Osteoarthritis (OA), Rheumatoid Arthritis (RA), Acute Pain Diarrhea, Dyspepsia, Abdominal Pain, Flatulence, Nausea May increase the risk of serious (& potentially fatal) cardiovascular thrombotic events, MI (Myocardial Infarction), & Stroke; May increase the risk for serious (& potentially fatal) GI adverse events including ulceration, bleeding, & perforation May reduce renal blood flow & compromise existing renal function (Avoid in patients with renal disease, heart failure, & cirrhosis)
Ibuprofen (PO) Motrin, Advil OTC Non-Steroidal Anti-Inflammatory Drug (NSAID) Osteoarthritis (OA), Rheumatoid Arthritis (RA), Acute Pain Diarrhea, Dyspepsia, Abdominal Pain, Flatulence, Nausea May increase the risk of serious (& potentially fatal) cardiovascular thrombotic events, MI (Myocardial Infarction), & Stroke; May increase the risk for serious (& potentially fatal) GI adverse events including ulceration, bleeding, & perforation May reduce renal blood flow & compromise existing renal function (Avoid in patients with renal disease, heart failure, & cirrhosis)
Meloxicam (PO) Mobic Non-Steroidal Anti-Inflammatory Drug (NSAID) Osteoarthritis (OA), Rheumatoid Arthritis (RA), Acute Pain Diarrhea, Dyspepsia, Abdominal Pain, Flatulence, Nausea May increase the risk of serious (& potentially fatal) cardiovascular thrombotic events, MI (Myocardial Infarction), & Stroke; May increase the risk for serious (& potentially fatal) GI adverse events including ulceration, bleeding, & perforation May reduce renal blood flow & compromise existing renal function (Avoid in patients with renal disease, heart failure, & cirrhosis)
Indomethacin (PO) Indocin Non-Steroidal Anti-Inflammatory Drug (NSAID) Osteoarthritis (OA), Rheumatoid Arthritis (RA), Acute Pain, Gout Diarrhea, Dyspepsia, Abdominal Pain, Flatulence, Nausea May increase the risk of serious (& potentially fatal) cardiovascular thrombotic events, MI (Myocardial Infarction), & Stroke; May increase the risk for serious (& potentially fatal) GI adverse events including ulceration, bleeding, & perforation May reduce renal blood flow & compromise existing renal function (Avoid in patients with renal disease, heart failure, & cirrhosis)
Naproxen (PO) Naprosyn, Anaprox, Aleve OTC Non-Steroidal Anti-Inflammatory Drug (NSAID) Osteoarthritis (OA), Rheumatoid Arthritis (RA), Acute Pain, Gout Diarrhea, Dyspepsia, Abdominal Pain, Flatulence, Nausea May increase the risk of serious (& potentially fatal) cardiovascular thrombotic events, MI (Myocardial Infarction), & Stroke; May increase the risk for serious (& potentially fatal) GI adverse events including ulceration, bleeding, & perforation May reduce renal blood flow & compromise existing renal function (Avoid in patients with renal disease, heart failure, & cirrhosis)
Ketorolac (PO, IV) Toradol Non-Steroidal Anti-Inflammatory Drug (NSAID) Pain Diarrhea, Dyspepsia, Abdominal Pain, Flatulence, Nausea May increase the risk of serious (& potentially fatal) cardiovascular thrombotic events, MI (Myocardial Infarction), & Stroke; May increase the risk for serious (& potentially fatal) GI adverse events including ulceration, bleeding, & perforation Indicated for short term use (≤ 5 days) May reduce renal blood flow & compromise existing renal function (Avoid in patients with renal disease, heart failure, & cirrhosis)
Celecoxib (PO) Celebrex Non-Steroidal Anti-Inflammatory Drug (NSAID), COX-2 Selective Osteoarthritis (OA), Rheumatoid Arthritis (RA), Acute Pain Diarrhea, Dyspepsia, Abdominal Pain, Flatulence, Nausea May increase the risk of serious (& potentially fatal) cardiovascular thrombotic events, MI (Myocardial Infarction), & Stroke; May increase the risk for serious (& potentially fatal) GI adverse events including ulceration, bleeding, & perforation May reduce renal blood flow & compromise existing renal function (Avoid in patients with renal disease, heart failure, & cirrhosis)
Cyclobenzaprine (PO) Flexeril, Amrix, Fexmid Skeletal Muscle Relaxant Muscle Spasm Drowsiness, Dizziness, Xerostomia, Fatigue Use may cause prolonged cardiac arrhythmias, & tachycardia; CI within 14 days of MAOI (Monoamine Oxidase Inhibitor) therapy
Baclofen (PO) --- Skeletal Muscle Relaxant Spasticity Drowsiness
Methocarbamol (PO) Robaxin Skeletal Muscle Relaxant Muscle Spasm Drowsiness
Lidocaine (Transdermal, IV) Transdermal: Lidoderm, IV: Xylocaine Transdermal: OTC Transdermal: Topical Analgesic IV: Antiarrhythmic Transdermal: Pain, IV: Ventricular Arrhythmias Transdermal: Dermatitis, Erythema, Urticaria, Skin Depigmentation, Skin Edema IV: Bradycardia Patch may remain in place for up to 12 hours in any 24-hour period, Patch may be cut
Colchicine (PO) Colcrys Antigout Agent Gout Diarrhea, Nausea, Vomiting, Bone Marrow Suppression, Myopathy (including Rhabdomyolysis)
Allopurinol (PO) Zyloprim Xanthine Oxidase Inhibitor Gout Diarrhea, Nausea, Rash, Leukopenia, Thrombocytopenia Rare association with severe (& potentially fatal) allopurinol hypersensitivity syndrome (Risk highest in certain Asian populations)
Succinylcholine (IV) Anectine Depolarizing Neuromuscular Blocking Agent Neuromuscular Blockade for Intubation or Procedures Hyperkalemia, Myalgia, Malignant Hyperthermia (Rare) Acute rhabdomyolysis & hyperkalemia leading to cardiac arrest & death in pediatric patients with undiagnosed skeletal muscle disease
Etanercept (SQ) Enbrel Anti-Tumor Necrosis Factor Alpha Inhibitor Rheumatoid Arthritis (RA) Infection, Injection Site Reaction, Headache, Nausea Serious Infections, Malignancies such as Lymphoma
Adalimumab (SQ) Humira Anti-Tumor Necrosis Factor Alpha Inhibitor Rheumatoid Arthritis (RA), Crohn's Disease, Ulcerative Colitis Infection, Injection Site Reaction, Headache, Nausea Serious Infections, Malignancies such as Lymphoma
Created by: nataliemvo
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