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CV 3

Pharmacologic CategoryGenericBrandClassificationIndicationKey Side effectUS Boxed WarningOther Notes
Anticoagulant, direct thrombin inhibitor dabigatran (PO) Pradaxa n/a AF (stroke prevention), VTE bleeding, dyspepsia premature discontinuation increases risk of thrombotic events; increased risk of epidural or spinal hematoma in patient undergoing spinal puncture swallow whole; dispense and store in original packaging; discard 4 months after opening
Anticoagulant, factor Xa inhibitor apixaban (PO) Eliquis n/a AF (stroke prevention), VTE bleeding premature discontinuation increases risk of thrombotic events; increased risk of epidural or spinal hematoma in patient undergoing spinal puncture n/a
Anticoagulant, factor Xa inhibitor rivaroxaban (PO) Xarelto n/a AF (stroke prevention), VTE, PAD bleeding premature discontinuation increases risk of thrombotic events; increased risk of epidural or spinal hematoma in patient undergoing spinal puncture n/a
Anticoagulant, vitamin K antagonist warfarin (PO) Coumadin, Jantoven n/a AF (stroke prevention), VTE bleeding, skin necrosis bleeding risk narrow therapeutic index drug (toxicity may occur at concentrations close to therapeutic range; therapeutic monitoring recommended with INR). dose dependent tablet colors; consistent vitamin K intake recommended; many drug interactions
Anticoagulant, low molecular weight heparin enoxaparin (SQ) Lovenox n/a ACS, VTE bleeding, HIT increased risk of epidural or spinal hematoma in patients undergoing spinal puncture do not expel air bubble from syringe prior to injection
Anticoagulant heparin (IV, SQ) n/a n/a ACS, VTE bleeding, hyperkalemia (chronic use), HIT n/a n/a
Antiplatelet agent clopidogrel (PO) Plavix n/a CAD, stroke bleeding diminished effectiveness in poor metabolizers n/a
Antiplatelet agent ticagrelor (PO) Brilinta n/a ACS bleeding, dyspnea significant, sometimes fatal bleeding; do not exceed aspirin >100 mg daily due to reduced ticagrelor effectiveness n/a
Antiplatelet agent aspirin (PO) Bayer, Bufferin, Ecotrin OTC ACS, stable angina, pain, stroke dyspepsia, heartburn, bleeding n/a CI in NSAID or salicylate allergy, children and teenagers with viral infection (due to Reye’s syndrome), can cause tinnitus in salicylate overdose
Vasodilator nitroglycerin (SL) Nitrostat n/a ACS, stable angina headache, flushing, syncope, dizziness n/a do not use with PDE-5 Inhibitors; tachyphylaxis (tolerance/ ↓ effectiveness); can aggravate angina causes by hypertrophic cardiomyopathy
Fibrinolytic alteplase (intracatheter, IV) Intracatheter: Cathflo Activase, IV: Activase n/a Intracatheter: catheter clearance IV: STEMI, acute ischemic stroke, PE bleeding n/a CI in patients with severe uncontrolled HTN
Created by: ziad5
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