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CV 2
| Pharmacologic Category | Generic | Brand | Indication | Key Side Effect | US Boxed Warnings | Other Notes |
|---|---|---|---|---|---|---|
| Mineralocorticoid receptor antagonist (MRA) | spironolactone (PO) | Aldactone | HTN, HF, ascites | gynecomastia, hyperkalemia, hypotension | n/a | n/a |
| Loop diuretic | furosemide (PO, IV) | Lasix | Volume overload | hypokalemia, hypomagnesemia, hyponatremia, hypotension | fluid and electrolyte loss | n/a |
| Loop diuretic | torsemide (PO) | Soaanz | Volume overload | hypokalemia, hypomagnesemia, hyponatremia, hypotension | n/a | n/a |
| Beta1-selective beta- blocker | atenolol (PO) | Tenormin | AF (rate control), CAD, HTN | bradycardia, hypotension | avoid abrupt discontinuation | masks symptoms of hypoglycemia |
| Beta1-selective beta- blocker | metoprolol tartrate (PO, IV) | Lopressor | AF (rate control), CAD, HTN | bradycardia, hypotension | avoid abrupt discontinuation | masks symptoms of hypoglycemia |
| Beta1-selective beta- blocker | metoprolol succinate (PO) | Toprol-XL | HF, AF (rate control), CAD, HTN | bradycardia, hypotension | n/a | masks symptoms of hypoglycemia |
| Beta1-selective beta- blocker | nebivolol (PO) | Bystolic | HTN | bradycardia, hypotension | n/a | masks symptoms of hypoglycemia |
| Beta1-selective beta- blocker | esmolol (IV) | Brevibloc | HTN, AF (rate control), hypertensive emergency | bradycardia, hypotension | n/a | masks symptoms of hypoglycemia; CI with pulmonary hypertension |
| Non-selective beta- blocker and alpha1 blocker | carvedilol (PO) | Coreg, Coreg CR | HF, AF (rate control), CAD, HTN | bradycardia, hypotension | n/a | masks symptoms of hypoglycemia |
| Non-selective beta- blocker and alpha1 blocker | labetalol (PO, IV) | Trandate | PO: HTN, IV: hypertensive crisis | bradycardia, hypotension | n/a | masks symptoms of hypoglycemia |
| Non-selective beta-blocker | propranolol (PO) | Inderal LA, Inderal XL | HTN, CAD, migraine prophylaxis | bradycardia, hypotension | n/a | masks symptoms of hypoglycemia |
| Alpha2 agonist | clonidine (PO, transdermal) | PO: Catapres, Transdermal: Catapres-TTS | HTN, ADHD | xerostomia, drowsiness, contact dermatitis (transdermal), hypotension | avoid epidural use | do not discontinue abruptly; taper to reduce rebound HTN |
| Direct arterial vasodilator | hydralazine (PO, IV) | n/a | HTN | hypotension, drug-induced lupus-like syndrome | n/a | CI in CAD |
| Beta1, beta2, and alpha1 agonist | epinephrine (IV, IM, SQ) | Adrenalin, EpiPen | Advanced cardiac life support, shock, anaphylaxis, bradycardia | tachyarrhythmias, peripheral ischemia, hyperglycemia | n/a | n/a |
| Alpha1 agonist (predominantly), beta1 and beta2 agonist | norepinephrine (IV) | Levophed | Shock | tachyarrhythmias, peripheral ischemia | extravasation (central line administration preferred) | n/a |