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GI 2

Pharmacologic CategoryGenericBrandClassificationIndicationKey Side effectsUS Boxed Warning Other notes
Histamine (H2) antagonist famotidine (PO, IV) Pepcid, Zantac 360 PO: OTC GERD, erosive esophagitis, SUP headache, constipation, diarrhea, mental status changes n/a n/a
Dopamine (D2) antagonist metoclopramide (PO, IV) Reglan n/a Gastroparesis, GERD, nausea, vomiting drowsiness, dystonia, akathisia, EPS, QTc prolongation, diarrhea, hyperprolactinemia may cause tardive dyskinesia, do not use >12 weeks CI with GI obstruction, perforation, or hemorrhage
Selective serotonin (5-HT3) antagonist ondansetron (PO, IV) Zofran n/a Nausea, vomiting headache, fatigue, constipation, QTc prolongation n/a n/a
Histamine (H1) antagonist promethazine (PO, IM, IV, PR) Phenergan n/a Motion sickness, nausea, vomiting drowsiness, dry mouth, blurred vision, QTc prolongation, EPS potential for fatal respiratory depression in patients < 2 years old; injection can cause peripheral extravasation (preferred parenteral route is IM) n/a
Histamine (H1) antagonist meclizine (PO) Bonine OTC Motion sickness, vertigo drowsiness, dry mouth, blurry vision n/a n/a
Antidiarrheal diphenoxylate and atropine (PO) Lomotil CS-V Diarrhea nausea, confusion, drowsiness, dizziness, xerostomia, tachycardia, urinary retention n/a do not use in diarrhea associated with enterotoxin- producing bacteria or in children <6 years of age
Proton pump inhibitor (PPI) dexlansoprazole (PO) Dexilant n/a GERD, PUD, erosive esophagitis, SUP headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD) n/a n/a
Proton pump inhibitor (PPI) esomeprazole (PO, IV) Nexium PO: OTC GERD, PUD, erosive esophagitis, SUP headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD) n/a n/a
Proton pump inhibitor (PPI) lansoprazole (PO) Prevacid OTC GERD, PUD, erosive esophagitis, SUP headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD) n/a n/a
Proton pump inhibitor (PPI) omeprazole (PO) Prilosec OTC GERD, PUD, erosive esophagitis, SUP headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD) n/a n/a
Proton pump inhibitor (PPI) pantoprazole (PO, IV) Protonix n/a GERD, PUD, erosive esophagitis, SUP headaches, abdominal pain, nausea, diarrhea, bone fracture, vitamin B12 deficiency, hypomagnesemia, increased risk of Clostridioides difficile associated diarrhea (CDAD) n/a n/a
Gastrointestinal protectant sucralfate (PO) Carafate n/a duodenal ulcers constipation, bezoar formation n/a take on an empty stomach; many drug interactions due to reducing absorption of other drugs
Created by: ziad5
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