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CNS 3
BDK 2025-2026
| Generic Name | Brand Name | Pharmacologic Category | Common Indications | Key Side Effects | US Boxed Warnings | Other Notes |
|---|---|---|---|---|---|---|
| lithium (PO) | Lithobid | antimanic agent | bipolar disorder | tremor, acne, hypothyroidism, weight gain, polyuria, polydipsia, GI upset | ability to promptly monitor levels is necessary | narrow therapeutic index drug (toxicity may occur at concentrations close to therapeutic range; therapeutic drug monitoring is recommended); avoid in pregnancy |
| sumatriptan (PO, intranasal, SQ) | Imitrex | antimigraine | migraine | fatigue, somnolence, dizziness, chest tightness, paresthesias | CI in ischemic heart disease, history of stroke or TIA, peripheral vascular disease, and rizatriptan (PO) Maxalt uncontrolled hypertension | |
| rizatriptan (PO) | Maxalt | antimigraine | migraine | fatigue, somnolence, dizziness, chest tightness, paresthesias | CI in ischemic heart disease, history of stroke or TIA, peripheral vascular disease, and rizatriptan (PO) Maxalt uncontrolled hypertension | |
| haloperidol (PO, IV, IM) | Haldol | 1st-generation antipsychotic | schizophrenia | sedation, EPS, parkinsonism, xerostomia, orthostatic hypotension, weight gain, QTc prolongation | elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | |
| clozapine (PO) | Clozaril | 2nd-generation antipsychotic | treatment resistant schizophrenia | sedation, constipation, orthostatic hypotension, sialorrhea, hyperglycemia, weight gain, neutropenia | may cause severe neutropenia; orthostatic hypotension, bradycardia, and syncope; seizures; may cause fatal myocarditis and cardiomyopathy; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | |
| aripiprazole (PO, IM) | PO/IV: Abilify; IM: Aristada | 2nd-generation antipsychotic | schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | akathisia, restlessness, sedation, EPS, constipation, orthostatic hypotension, weight gain | antidepressants increase the risk of suicidal thinking and behavior in children, adolescents and young adults; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | |
| quetiapine (PO) | Seroquel, Seroquel XR | 2nd-generation antipsychotic | schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | sedation, EPS, constipation, orthostatic hypotension, weight gain | antidepressants increase the risk of suicidal thinking and behavior in children, adolescents and young adults; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | |
| lurasidone (PO) | Latuda | 2nd-generation antipsychotic | schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | sedation, EPS, constipation, orthostatic hypotension, weight gain | antidepressants increase the risk of suicidal thinking and behavior in children, adolescents and young adults; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | CI with strong 3A4 inhibitors and inducers |
| olanzapine (PO, IM) | Zyprexa | 2nd-generation antipsychotic | schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | sedation, EPS, xerostomia, constipation, orthostatic hypotension, weight gain, hyperglycemia | elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death | |
| risperidone (PO, IM) | PO: Risperdal; IM: Risperdal Consta | 2nd-generation antipsychotic | schizophrenia | sedation, EPS, xerostomia, constipation, orthostatic hypotension, weight gain, hyperglycemia | elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death |