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CNS 4
| Pharmacologic Category | Generic | Brand | Classification | Indication | Key side effects | US Boxed Warnings |
|---|---|---|---|---|---|---|
| Anticonvulsant | carbamazepine (PO) | Tegretol | n/a | Seizure disorders, bipolar disorder | dizziness, drowsiness, headache, ataxia, nausea, vomiting, hyponatremia | risk of serious dermatologic reactions (including SJS and TEN) in patients with certain genetic predisposition; may cause aplastic anemia and agranulocytosis |
| Anticonvulsant | lamotrigine (PO) | Lamictal | n/a | Seizure disorders, bipolar disorder | nausea, vomiting, somnolence, skin rash, alopecia | risk of serious dermatologic reactions, including SJS |
| Anticonvulsant | divalproex (valproic acid derivative) (PO) | Depakote, Depakote ER | n/a | Seizure disorders, bipolar disorder, migraine prophylaxis | drowsiness, weight gain, tremor, alopecia, thrombocytopenia, hyperammonemia | may cause fatal hepatic failure; may cause life- threatening pancreatitis; fetal toxicity |
| Anticonvulsant | topiramate (PO) | Topamax | n/a | Seizure disorders, migraine prophylaxis | somnolence, dizziness, memory impairment, weight loss | n/a |
| Anticonvulsant | levetiracetam (PO, IV) | Keppra | n/a | Seizure disorders | somnolence, dizziness, nausea, vomiting, weakness, asthenia, psychotic symptoms, agitation | n/a |
| Anticonvulsant | oxcarbazepine (PO) | Trileptal | n/a | Seizure disorders | somnolence, dizziness, diplopia, nausea, vomiting, ataxia, hyponatremia | n/a |
| Anticonvulsant | gabapentin (PO) | Neurontin | n/a | Seizure disorders, neuropathic pain | somnolence, dizziness, ataxia, fatigue, diplopia, xerostomia, blurry vision, peripheral edema, weight gain | n/a |
| Anticonvulsant | pregabalin (PO) | Lyrica | CS-V | Seizure disorders, neuropathic pain | somnolence, dizziness, ataxia, fatigue, diplopia, xerostomia, blurry vision, peripheral edema, weight gain | n/a |