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CNS 3

Pharmacologic CategoryGenericBrandIndication Key Side EffectsUS Boxed WarningsOther Notes
Antimanic agent lithium (PO) Lithobid Bipolar disorder tremor, acne, hypothyroidism, weight gain, polyuria, polydipsia, GI upset ability to promptly monitor levels is necessary narrow therapeutic index drug (toxicity may occur at concentrations close to therapeutic range; therapeutic drug monitoring is recommended); avoid in pregnancy
Antimigraine sumatriptan (PO, intranasal, SQ) Imitrex Migraine fatigue, somnolence, dizziness, chest tightness, paresthesias n/a CI in ischemic heart disease, history of stroke or TIA, peripheral vascular disease, and uncontrolled hypertension
Antimigraine rizatriptan (PO) Maxalt Migraine fatigue, somnolence, dizziness, chest tightness, paresthesias n/a CI in ischemic heart disease, history of stroke or TIA, peripheral vascular disease, and uncontrolled hypertension
First-generation antipsychotic haloperidol (PO, IV, IM) Haldol Schizophrenia sedation, EPS, parkinsonism, xerostomia, orthostatic hypotension, weight gain, QTc prolongation elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death n/a
Second- generation antipsychotic clozapine (PO) Clozaril Treatment- resistant schizophrenia sedation, constipation, orthostatic hypotension, sialorrhea, hyperglycemia, weight gain, neutropenia cause severe neutropenia; cause orthostatic hypotension, bradycardia, and syncope; cause seizures; may cause fatal myocarditis and cardiomyopathy; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk death n/a
Second- generation antipsychotic aripiprazole (PO, IM) PO/IM: Abilify; IM: Aristada Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) akathisia, restlessness, sedation, EPS, constipation, orthostatic hypotension, weight gain antidepressants increase the risk of suicidal thinking and behavior in children, adolescents and young adults; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death n/a
Second- generation antipsychotic quetiapine (PO) Seroquel, Seroquel XR Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) sedation, EPS, constipation, orthostatic hypotension, weight gain antidepressants increase the risk of suicidal thinking and behavior in children, adolescents and young adults; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death n/a
Second- generation antipsychotic lurasidone (PO) Latuda Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) sedation, EPS, constipation, orthostatic hypotension, weight gain antidepressants increase the risk of suicidal thinking and behavior in children, adolescents and young adults; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death CI with strong 3A4 inhibitors and inducers
Second- generation antipsychotic olanzapine (PO, IM) Zyprexa Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) sedation, EPS, xerostomia, constipation, orthostatic hypotension, weight gain, hyperglycemia elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death n/a
Second- generation antipsychotic risperidone (PO, IM) PO: Risperdal IM: Risperdal Consta Schizophrenia sedation, EPS, xerostomia, constipation, orthostatic hypotension, weight gain, hyperglycemia elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death n/a
Created by: ziad5
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