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Non-Medical Drug Use

QuestionAnswer
Define "drug abuse"? Use of a drug in a way that differs from the accepted patterns in a society or Use of drugs in a manner which causes major and continuing problems in life
Define "experimental" non-medical drug use? Use of a drug on a few occasions because of curiosity about it
Define "Recreational" non-medical drug use? The casual use of modest amounts of a drug for its pleasurable effects
Define "Circumstantial" non-medical drug use? Use of a drug in certain situations
Define "Compulsive " non-medical drug use or drug dependence? Continued use of a drug despite adverse medical or social consequences
Define "Tolerance"? Decreased response to a given dose of drug after repeated doses d/t Pharmacokinetic, pharmacodynamic (downregulation or 2nd messengers), behavioral reasons
Define "Psychological dependence"? Drug needed for optimal state of mental well-being
What is the "Minimax Principle"? drug minimizes discomfort or maximizes pleasure
Define "Physical dependence"? An altered physiological state produced by repeated use of a drug, which requires continued use of drug in order to prevent an abstinence or withdrawal syndrome
Define "Abstinence syndrome"? A physiological reaction to the absence of a drug to which a person is physically dependent
Define "Cross dependence"? The ability of one drug to block the withdrawal syndrome of another drug and to maintain the dependent state
Define "Addiction"? An extreme pattern of compulsive drug use with a high possibility of relapse after withdrawal
What is the DSM IV definition of "Substance dependence"? A cluster of symptoms indicating that the individual continues use of the substance despite significant substance-related problems
A person may initiate drug use in order to...? Escape from reality; Obtain a sense of euphoria; Escape high levels of anxiety; Gain membership in a social group; Relieve physical pain; Bolster a poor self image; Enhance introspection or creativity; Have a novel experience
What characteristics are common in users that are considered "vulnerable"? Impulsive nature; Rebelliousness; Low frustration; tolerance; Depressed; Anxious; Antisocial; More sensitive to euphoric effects; Especially sensitive to social pressures
What is the "brain reward system"? Brain reward circuit initiated by stimulation or disinhibition of DA neurons in ventral tegmentum. Terminal projections of these neurons release dopamine in nucleus accumbens, resulting in reward.
What is the potential site of action for cocaine and amphetamines in the "brain reward system"? nucleus accumbens. This nucleus is thought to play an important role in reward, pleasure, and addiction
What is the ventral tegmentum area? is part of the midbrain, lying close to the substantia nigra. It is rich in dopamine and serotonin neurons, and is part of two major dopamine pathways: mesolimbic and mesocortical. It is considered to be part of the pleasure system, or reward circuit
Created by: psfisher50
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