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Endocrine 1

Pharmacologic CategoryGenericBrandClassificationIndicationsKey Side effectsOther notesUS Boxed Warning
Biguanide metformin (PO) Fortamet, Glumetza n/a Type 2 DM, PCOS Key Side Effects: diarrhea, nausea, vomiting, Vitamin B12 deficiency Other Notes: CI with eGFR <30 US Boxed Warnings: lactic acidosis
Dipeptidyl peptidase (DPP-4) inhibitor sitagliptin (PO) Januvia, Zituvio n/a Type 2 DM Key Side Effects: nasopharyngitis n/a n/a
Sodium-glucose cotransporter inhibitor 2 (SGLT2 inhibitor) empagliflozin (PO) Jardiance n/a Type 2 DM, HF, CKD Key Side Effects: genital mycotic infections, UTI n/a n/a
Sodium-glucose cotransporter inhibitor 2 (SGLT2 inhibitor) dapagliflozin (PO) Farxiga n/a Type 2 DM, HF, CKD Key Side Effects: genital mycotic infections, UTI n/a n/a
Sulfonylurea glimepiride (PO) Amaryl n/a Type 2 DM Key Side Effects: hypoglycemia, weight gain n/a n/a
Sulfonylurea glipizide (PO) Glucotrol, Glucotrol XL n/a Type 2 DM Key Side Effects: hypoglycemia, weight gain n/a n/a
Thiazolidinedione (TZD) pioglitazone (PO) Actos n/a Type 2 DM Key Side Effects: peripheral edema, weight gain, upper respiratory tract infection; increased risk of fractures and bladder cancer n/a US Boxed Warnings: may exacerbate congestive heart failure and CI in NYHA Class III and IV
Glucagon-like peptide-1 (GLP-1) receptor agonist dulaglutide (SQ) Trulicity n/a Type 2 DM Key Side Effects: nausea, vomiting, diarrhea, pancreatitis n/a US Boxed Warning: may increase risk of thyroid c-cell tumor
Glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide (SQ) Victoza, Saxenda n/a Type 2 DM, chronic weight management Key Side Effects: nausea, vomiting, diarrhea, constipation, pancreatitis n/a US Boxed Warning: may increase risk of thyroid c-cell tumor, CI in personal or family history of medullary thyroid cancer
Glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide (PO, SQ) SQ: Ozempic, Wegovy PO: Rybelsus n/a Type 2 DM, chronic weight management Key Side Effects: nausea, vomiting, diarrhea, constipation, pancreatitis n/a US Boxed Warning: may increase risk of thyroid c-cell tumor, CI in personal or family history of medullary thyroid cancer
Dual GLP-1 and glucose- dependent insulinotropic polypeptide (GIP) agonist tirzepatide (SQ) Mounjaro, Zepbound n/a Type 2 DM, chronic weight management Key Side Effects: nausea, vomiting, diarrhea, constipation, increased heart rate, pancreatitis n/a US Boxed Warning: may increase risk of thyroid c-cell tumor
Insulin, long acting insulin glargine (SQ) Lantus, Toujeo, Basaglar n/a Type 1 DM, type 2 DM Key Side Effects: hypoglycemia, weight gain n/a n/a
Insulin, intermediate acting insulin NPH (SQ) Humulin N, Novolin N OTC Type 1 DM, type 2 DM Key Side Effects: hypoglycemia, weight gain n/a n/a
Insulin, rapid acting insulin aspart (SQ) Novolog n/a Type 1 DM, type 2 DM Key Side Effects: hypoglycemia, weight gain n/a n/a
Insulin, rapid acting insulin lispro (SQ) Humalog n/a Type 1 DM, type 2 DM Key Side Effects: hypoglycemia, weight gain n/a n/a
Insulin, short-acting insulin regular (SQ, IV) Humulin R, Novolin R SQ: OTC Type 1 DM, type 2 DM, DKA Key Side Effects: hypoglycemia, weight gain n/a n/a
Created by: ziad5
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