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Antiseizure Meds
Neurology/Psychiatry
| Question | Answer |
|---|---|
| What is the MOA for Briviact (briviracetam)? | SV2A modulation |
| Does Briviact (briviracetam) have DDIs? | Minimal |
| What dosage forms does Briviact (briviracetam) come in? | Tablet, oral solution, and IV |
| Is Briviact (briviracetam) a controlled substance? | It is a C-V |
| Who should avoid taking Briviact (briviracetam)? | Patients with a mood or behavioral disorder |
| What BBW does Briviact (briviracetam) have? | None |
| What are the CIs of Briviact (briviracetam)? | None |
| What is the brand name of briviracetam? | Briviact |
| What is the brand name of cannabidiol? | Epidiolex |
| What BBW does Epidiolex (cannabidiol) have? | None |
| What are the CIs of Epidiolex (cannabidiol)? | None |
| Are there DDIs with Epidiolex (cannabidiol)? | Many DDIs |
| What dosage forms does Epidiolex (cannabidiol) come in? | Oral solution |
| Notes for Epidiolex (cannabidiol): | - Lennox Gastaut - Dravet Syndrome - Tuberous sclerosis |
| What is the brand name for carbamazepine? | Tegretol |
| What is the MOA for Epidiolex (cannabidiol)? | Unknown |
| What is the MOA for Tegretol (carbamazepine)? | Sodium (Na) Channel Blocker |
| What are BBWs for Tegretol (carbamazepine)? | - Agranulocytosis - Aplastic anemia - Dermatological reactions (HLA-B*15:02) |
| What are the CIs for Tegretol (carbamazepine)? | - Hx of bone marrow depression - Use with MAOIs or nefazodone |
| Is Tegretol (carbamazepine) an inducer or inhibitor? | - Auto-Inducer - Strong 3A4 inducer - Inducer of 1A2, 2B6, 2C19, 2C9, P-gp |
| What dosage forms does Tegretol (carbamazepine) come in? | Multiple oral forms |
| Can Tegretol (carbamazepine) be used during pregnancy? | No, it can cause Fetal Harm |
| What are other uses for Tegretol (carbamazepine)? | - Mood stabilization - Trigeminal neuralgia |
| What is the brand name of clobazam? | Onfi |
| What are BBWs for Onfi (clobazam)? | - Concurrent use with opioids - Abuse & addiction - Dependence & withdrawal reactions |
| What are the CIs for Onfi (clobazam)? | None |
| Are there DDIs with Onfi (clobazam)? | - Alcohol - Opioids |
| What dosage forms does Onfi (clobazam) come in? | Oral forms only |
| Is Onfi (clobazam) a controlled substance? | C-IV |
| Notes for Onfi (clobazam): | Lennox Gastaut |
| What is the brand name for divalproex/valproate? | Depakote |
| What are the BBWs for Depakote (divalproex/valproate)? | - Hepatotoxicity - Patients with mitochondrial disease - Teratogenicity - Pancreatitis |
| What are the CIs for Depakote (divalproex/valproate)? | - Hepatic disease - Urea cycle disorders |
| Are there DDIs with Depakote (divalproex/valproate)? | Many DDIs |
| Is Depakote (divalproex/valproate) an inducer or inhibitor? | CYP Inhibitor |
| What dosage forms does Depakote (divalproex/valproate) come in? | - Multiple oral forms - IV |
| Can Depakote (divalproex/valproate) be used during pregnancy? | No, it can cause Fetal Harm |
| Notes for Depakote (divalproex/valproate)? | - Highly protein bound |
| What are other uses for Depakote (divalproex/valproate)? | - Migraine prevention - Migraine treatment - Mood stabalization |
| What is the brand name for eslicarbazepine acetate? | Aptiom |
| What is the MOA for Depakote (divalproex/valproate)? | GABA modulation |
| What is the MOA for Aptiom (eslicarbazepine acetate)? | Sodium (Na) Channel Blocker |
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