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PHO 3

PAIN, HEMATOLOGY, AND ONCOLOGY 3

Pharmacologic CategoryGeneric Brand ClassificationCommon IndicationsEssential Knowledge
Antimetabolite (folic acid antagonist) methotrexate (PO, IV, IT) Trexall Rheumatoid arthritis, Crohn’s Disease, psoriasis, various hematologic and solid tumors Key Side Effects: stomatitis, diarrhea, nausea, vomiting, thrombocytopenia, leukopenia, increased hepatic transaminases, pulmonary fibrosis (rare)
Antineoplastic agent, platinum-based compound cisplatin (IV, IT, IP) Kemoplat Advanced bladder, ovarian, and testicular cancer; various cancers Key Side Effects: bone marrow suppression, nausea, vomiting, nephrotoxicity, neurotoxicity, ototoxicity
Antineoplastic agent, anthracycline doxorubicin (IV) Adriamycin Adjuvant therapy for breast cancer, various cancers Key Side Effects: cardiomyopathy, alopecia, nausea, vomiting, bone marrow suppression
Antineoplastic agent, monoclonal antibody pembrolizumab (IV) Keytruda Various cancers Key Side Effects: peripheral edema, pruritus, skin rash, endocrine and metabolic abnormalities, constipation, diarrhea, nausea, vomiting, hematuria, anemia, increased liver enzymes, fatigue, musculoskeletal pain, increased serum creatinine, dyspnea
Aromatase inhibitor anastrozole (PO) Arimidex Hormone receptor-positive breast cancer Key Side Effects: fatigue, rash, flushing, hot flashes, arthralgia, nausea, vomiting, hypertension, peripheral edema, osteoporosis
Selective estrogen receptor modulator (SERM) tamoxifen (PO) Soltamox Hormone receptor-positive breast cancer Key Side Effects: hot flashes/night sweats, vaginal bleeding/discharge, decreased bone density (in premenopausal females)
Created by: arizvi
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