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PHO 1

PAIN, HEMATOLOGY, AND ONCOLOGY 1

Pharmacologic CategoryGeneric Brand ClassificationCommon IndicationsEssential Knowledge
Opioid analgesic fentanyl (transdermal, IV) Transdermal: Duragesic, IV: Sublimaze CS-II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) BBW: potential for errors when converting between dosage forms; use w/ CYP3A4 inhibitors can increase fentanyl concentrations;
Opioid analgesic hydromorphone (PO, IV) Dilaudid CS-II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warning: risk of medication errors with high-potency hydromorphone, use in opioid-tolerant patients only
Opioid analgesic morphine (extended release) (PO) MS Contin, Kadian CS-II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warning: coingestion with alcohol may result in potentially fatal overdose of morphine
Opioid analgesic morphine (immediate release) (PO, IV, IM, PR) IV: Duramorph, Infumorph CS-II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related) US Boxed Warning: use with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can increase oxycodone concentrations
Opioid analgesic oxycodone (PO) OxyContin, Roxicodone CS-II Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, pruritus, respiratory depression (dose-related)
Opioid analgesic methadone (PO, IV) Dolophine CS-II Opioid use disorder, severe chronic pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, respiratory depression (dose-related), QTc prolongation BBW: QTc prolongation and arrhythmia concomitant use with CYP3A4, 2B6, 2C19, or 2D6 increase conc.
Analgesic (non-opioid), antipyretic acetaminophen (PO, PR, IV) PO/PR: Tylenol, IV: Ofirmev PO, PR: OTC Pain, fever Key Side Effects: nausea, vomiting, increased hepatic transaminases
Central analgesic; partial opioid agonist tramadol (PO) Ultram, Ultram ER CS-IV Pain Key Side Effects: dizziness, drowsiness, nausea, vomiting, constipation, respiratory depression (dose-related)
Created by: arizvi
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