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ENDOCRINE 3

Pharmacologic CategoryGenericBrandClassificationCommon IndicationsEssential Knowledge
Androgen testosterone gel (topical) AndroGel, Fortesta, Vogelxo CS-III Male hypogonadism Key Side Effects: contact dermatitis, acne, increased prostate specific antigen (PSA), emotional lability, HTN BBW: secondary exposure may result in virilization CI in males with breast or prostate cancer and pregnant women; apply in the morning
Bisphosphonate alendronate (PO) Fosamax Osteoporosis Key Side Effects: dyspepsia, gastroesophageal reflux disease, hypocalcemia, atypical fractures, osteonecrosis of the jaw Other Notes: CI in patients with hypocalcemia or abnormalities of the esophagus; administer ≥30 minutes before food or drink
Vitamin D analog cholecalciferol (vitamin D3) (PO) OTC Dietary supplement, osteoporosis prevention Key Side Effect: vitamin D toxicity (nausea, vomiting, loss of appetite, constipation, confusion, weakness) Other Note: CI with hypercalcemia
Phosphodiesterase-5 enzyme (PDE5) inhibitor sildenafil (PO) Viagra, Revatio ED, PAH Key Side Effects: priapism, headache, flushing, visual disturbance, dyspepsia, back pain (mostly with tadalafil), hearing or vision loss (rare) Other Notes: CI with concomitant use of nitrates (may cause severe hypotension)
Phosphodiesterase-5 enzyme (PDE5) inhibitor tadalafil (PO) Cialis, Adcirca ED, BPH, PAH Key Side Effects: priapism, headache, flushing, visual disturbance, dyspepsia, back pain (mostly with tadalafil), hearing or vision loss (rare) Other Notes: CI with concomitant use of nitrates (may cause severe hypotension)
Thyroid product levothyroxine (PO, IV) Synthroid, Levoxyl, Unithroid Hypothyroidism Key Side Effects: weight loss, palpitations, diarrhea, insomnia, heat intolerance US Boxed Warnings: not intended for use for weight loss Other Notes: narrow therapeutic index drug (therapeutic monitoring is recommended);
Thyroid product thyroid, desiccated (PO) Armour Thyroid Hypothyroidism Key Side Effects: weight loss, palpitations, diarrhea, insomnia, heat intolerance US Boxed Warnings: not intended for use for weight loss Other Notes: narrow therapeutic index drug (therapeutic monitoring is recommended);
CNS stimulant, anorexiant phentermine (PO) Adipex-P Obesity Key Side Effects: tachycardia, hypertension, nausea, dizziness, xerostomia, agitation Notes: only approved for short-term use; CI in those with a history of CV disease or drug abuse, pregnancy, hyperthyroidism, or within 14 days of MAOI therapy
Created by: arizvi
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