Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
PCOL Finals
Parkinsonsim,
| Question | Answer |
|---|---|
| Primary tx, Drug of choice for Parkinsonism | Levodopa |
| Reduced peripheral metabolism of levodopa when combined with? | Carbidopa |
| Part of the brain where dopaminergic neurons are destroyed | Substantia nigra (basal ganglia) |
| Drugs that increase dopamine levels in the brain. | Dopamimetics |
| If drugs aren't curative, what are they used for? | Treat symptoms |
| Why are dopamimetics lipophilic? | To cross the BBB |
| Incidence of parkinsonism increase risk when which vitamin is lacking? | Vitamin D |
| What neurotransmitter increases levels when dopamine decreases? | Acetylcholine |
| Symptom which writings become smaller | Micrografia |
| Symptom which muscles jerks involuntarily, unpredictably, and irregular | Chorea |
| Sudden coordinative abnormal/repetitive movements | Tics |
| Type of Parkinson disease where there is only minimal to no dopamine deficiency at all but has additional symptoms and is difficult to treat | Atypical |
| The primary pathology is dopamine deficiency but has good response to drugs. Can later on have falling and dementia | Idiopathic |
| Type of parkinsonism wherein the disease is caused by disease or medication | Secondary |
| Peripheral metabolism of levodopa decreases, Plasma levels of of levodopa increase, protects levodopa. | Carbidopa |
| 3-(3, 4-dihydroxyphenyl)L-alanine: drug of choice for parkinsonism | Levodopa |
| TRUE or FALSE: Levodopa, when used for a long period of time, increases efficacy and tolerance develops. | FALSE. (Decreases efficacy) |
| Adverse effects of L-Dopa | Anorexia, Nausea/vomiting, Behavioral effects, Choreoathetosis |
| You do this to reverse the tolerance and increase the effect again., and alleviate A/E. Usually for 3-21 days. | Drug Holiday |
| This increases the breakdown of L-Dopa (ex. when you take Vit B6) | Drug interaction |
| Selective Catechol-o-methyltransferase inhibitors | Tolcapone and Entacapone |
| Which of the selective COMT Inhibitors have longer duration of action and is less hepatotoxic? A. Tolcapone B. Entolcapone C. Entacapone D. Alcapone | C. Entacapone |
| BRAND name of the generic name: Levodopa+Carbidopa+Entacapone | Stalevo |
| The benefits of L-Dopa begins to diminish at what year/s? | 3-4 years |
| Prolongs the action of L-Dopa by diminishing its peripheral metabolism | COMT inhibitors |
| Give the two (2) Dopamine Agonists Derivatives | Ergot derivative and Non-ergot derivative |
| What fungi infects plants like grains and rye? | Ergot/Claviceps purpurea |
| This ergot derivative is not commonly used because it can increase pulmonary fibrosis, but is useful for management of hyperprolactinemia | Bromocriptine |
| This ergot derivative is not used because it is associated w/ Valvular Heart Disease. | Pergolide |
| Inflamed and stiff heart valves | VHD (Valvular Heart disease) |
| This non ergot derivative is a potent dopamine agonist, by using subcutaneous injection of HCl salt to relief akinesia temporarily | Apomorphine |
| HCl salt SC Inj. brand name that causes significant nausea | Apokyn |
| Adverse effects associated with ergot derivatives | Painless digital vasospasm |
| which MAO inhibitor metabolizes NE, 5HT, DA neurotransmitters | MAO-A |
| MAO inhibitor that metabolized dopamine SELECTIVELY | MAO-B |
| Selective MAO-B Irreversible inhibitor at normal doses that retards breakdown of dopamine, enhancing the antiparkinsonism of L-Dopa, but may also cause insomnia | Selegiline |
| More potent than selegiline in preventing MPTP-induced parkinsonism | Rasagiline |
| A protoxin compound where parkinsonism symptoms can occur when digested. Clue: (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) | MPTP |
| TRUE or FALSE: Phenylephrine can be given when the px. taking MAO inhibitors gets fever and colds | FALSE. (any OTC drug preparations have drug interactions with MAO inhibitors may they be selective of not) |
| TRUE or FALSE: Tricyclic antidepressants or TCA and SSRI can reuptake serotonin inhibitors. | TRUE. |
| TRUE or FALSE: Tyramine rich foods like kimchi, wine, or any fermented foods are contraindications of Dopamine agonists | FALSE. (CI of MAO inhibitors) |
| An antiviral agent that can be used as dopamine agonist itself but is less efficacious than L-Dopa. It can also induce CNS effects, Tolerance develops more readily and is also used for tx. of Influenza. | Amantadine |
| Skin adverse effect (fishnet like appearance) when taking Amantadine | Livedo Reticularis |
| Centrally acting antimuscarinics, improving tremors, rigidity, and has little effect on bradykinesia | Anticholinergics |
| Anticholinergics include? Clue: Mercedes benz beeping on the tricycle inside the Parking | BENZtropine mesylate BIPeridine TRIhexyphenidyl |
| Enzyme that is crucial for producing Dopamine (from L-Dopa) | Aromatic L-amino acid decarboxylase (AADC) |
| MAO-B is primarily found on what cell? | Glial cells |
| What is the mechanism of action of Amantadine in Parkinsonism? | Increases dopamine synthesis and release |
| Which dopamine agonist is delivered via transdermal patch? | Rotigotine |
| Pergolide can induce a problem with the? | Heart |
| Bromodiptine can induce a problem with the? | Lungs |
Created by:
cesvl
Popular Pharmacology sets