Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Dislipidemias

QuestionAnswer
Estatinas (General) Mecanismo: Reducción de LDL-C y aumento de HDL-C. RAMs críticos: - Miopatía - Rabdomiólisis - Hepatotoxicidad Monitorización: - Perfil lipídico a 12 semanas - CK basal y ante síntomas musculares - Transaminasas a los 3 meses
Rosuvastatina Potencia: Alta Dosis: 5-40 mg/día Dosis ERC: - TFG <30: 10 mg/día Interacciones clave: - Gemfibrozilo: ↑ 2x niveles (evitar) - Warfarina: Monitorizar INR
Consideraciones Rosuvastatina RAMs frecuentes: -Proteinuria leve (no progresiva) - Cefalea, mialgias Ventajas en Chile: - Metabolismo independiente de CYP450 - Menor riesgo de interacciones
Atorvastatina Potencia: Alta Dosis: 10-80 mg/día Dosis ERC: Sin ajuste. Interacciones peligrosas: - Inhibidores CYP3A4: Claritromicina, itraconazol (↑ toxicidad) - Gemfibrozilo: Contraindicado
Consideraciones Atorvastatina RAMs distintivos: - Mayor riesgo de hiperglicemia vs. otras estatinas - Insomnio (5% pacientes) Contexto chileno: - Primera elección en síndrome coronario agudo
Fibratos (General) Mecanismo: Reducción de TG RAMs críticos: - Molestias GI - Miopatía (↑ riesgo con estatinas) - Colelitiasis (10-20%) - Elevación transaminasas
Fenofibrato Dosis: 100-200 mg/día Dosis ERC: - TFG <30: Contraindicado Interacciones: - Resinas (colestiramina): Disminuyen absorción (separar 2h) - Warfarina: ↑ efecto anticoagulante
Consideraciones Fenofibrato Monitorización: - TG a las 12 semanas - Función renal cada 6 meses Ventajas en Chile: -Menor riesgo de interacciones con estatinas - Perfil seguro en diabéticos
Ezetimibe Mecanismo: Inhibe absorción intestinal de colesterol Indicación: - Adyuvante a estatinas si no se alcanza meta LDL - Intolerancia a estatinas Dosis: 10 mg/día Dosis ERC: Sin ajuste
Consideraciones Ezetimibe RAMs: - Diarrea (5%) - Dolor articular (raro) Efectividad: - ↓ LDL-C adicional 15-20% con estatina
Diagnóstico Criterios dislipidemia: - LDL ≥160 mg/dL (hipercolesterolemia) - HDL <40-50 mg/dL (Hombre/Mujer) - TG ≥150 mg/dL (hipertrigliceridemia) Signos clínicos: -Xantomas - Xantelasmas - Arco corneal
Interacciones Críticas Combinaciones peligrosas: - Estatina + Gemfibrozilo: ↑ 80x riesgo rabdomiólisis - Simvastatina + Amiodarona: ↑ toxicidad muscular Fármacos que ↑ TG: - Tiazidas - Betabloqueadores - Tamoxifeno - Corticoides
Created by: EliasPoblete
Popular Pharmacology sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards