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CNS 1
| Generic Name | Brand Name | Pharmacologic Category | Common Indications | Essential Knowledge |
|---|---|---|---|---|
| mirtazapine (PO) | Remeron | Alpha2 antagonist | MDD | Key Side Effects: drowsiness, weight gain, xerostomia, increased appetite, constipation US Boxed Warnings: increased risk of suicidal thinking and behavior in children, adolescents, and young adults |
| bupropion (PO) | Wellbutrin SR, Wellbutrin XL | Norepinephrine-dopamine reuptake inhibitor | MDD | Side Effects: fast HR, headache, agitation, dizziness, insomnia, weight loss, dry mouth Boxed Warnings: ↑ suicide risk in youth; possible serious psych effects Notes: ↑ seizure risk; CI in seizure or eating disorders |
| atomoxetine (PO) | Strattera | Selective norepinephrine reuptake inhibitor | MDD | Key Side Effects: hypertension, tachycardia, headache, xerostomia, nausea, vomiting, constipation, decreased appetite, insomnia US Boxed Warnings: increased risk of suicidal ideation in children or adolescents Other Notes: CI within 14 days of MAOI |
| desvenlafaxine (PO) | Pristiq | Serotonin-norepinephrine reuptake inhibitor (SNRI) | MDD | Key Side Effects: HA, xerostomia, N/V, constipation, ↓ appetite, insomnia. diaphoresis, HTN , sexual dysfunction BBW: increased risk of suicidal ideation in children or adolescents Other Notes: CI within 14 days of MAOI; do not discontinue abruptly |
| duloxetine (PO) | Cymbalta | Serotonin-norepinephrine reuptake inhibitor (SNRI) | MDD, neuropathic pain | Key Side Effects: HA, xerostomia, N/V, constipation, ↓ appetite, insomnia. diaphoresis, HTN , sexual dysfunction BBW: increased risk of suicidal ideation in children or adolescents Other Notes: CI within 14 days of MAOI; do not discontinue abruptly |
| venlafaxine (PO) | Effexor XR | Serotonin-norepinephrine reuptake inhibitor (SNRI) | MDD | Key Side Effects: HA, xerostomia, N/V, constipation, ↓ appetite, insomnia. diaphoresis, HTN , sexual dysfunction BBW: increased risk of suicidal ideation in children or adolescents Other Notes: CI within 14 days of MAOI; do not discontinue abruptly |
| citalopram (PO) | Celexa | Selective serotonin reuptake inhibitor (SSRI) | MDD | Side Effects: drowsiness, insomnia, N/V, dry mouth, sexual dysfunction, headache, sweating Boxed Warning: ↑ suicide risk in youth Notes: CI with MAOI (≤14 days); taper off (except fluoxetine) |
| fluoxetine (PO) | Prozac | Selective serotonin reuptake inhibitor (SSRI) | MDD | Side Effects: drowsiness, insomnia, N/V, dry mouth, sexual dysfunction, headache, sweating Boxed Warning: ↑ suicide risk in youth Notes: CI with MAOI (≤14 days); taper off (except fluoxetine) |
| escitalopram (PO) | Lexapro | Selective serotonin reuptake inhibitor (SSRI) | MDD | Side Effects: drowsiness, insomnia, N/V, dry mouth, sexual dysfunction, headache, sweating Boxed Warning: ↑ suicide risk in youth Notes: CI with MAOI (≤14 days); taper off (except fluoxetine) |
| paroxetine (PO) | Paxil | Selective serotonin reuptake inhibitor (SSRI) | MDD | Side Effects: drowsiness, insomnia, N/V, dry mouth, sexual dysfunction, headache, sweating Boxed Warning: ↑ suicide risk in youth Notes: CI with MAOI (≤14 days); taper off (except fluoxetine) |
| sertraline (PO) | Zoloft | Selective serotonin reuptake inhibitor (SSRI) | MDD | Side Effects: drowsiness, insomnia, N/V, dry mouth, sexual dysfunction, headache, sweating Boxed Warning: ↑ suicide risk in youth Notes: CI with MAOI (≤14 days); taper off (except fluoxetine) |
| trazodone (PO) | Desyrel | Serotonin reuptake inhibitor | Insomnia, MDD | Key Side Effects: sedation, headache, dizziness, xerostomia, nausea, priapism US Boxed Warnings: increased risk of suicidal thinking and behavior in children, adolescents and young adults |
| amitriptyline (PO) | Elavil | Tricyclic antidepressant (TCA) | MDD, diabetic neuropathy, migraine prophylaxis | Side Effects: dizziness, drowsiness, low BP, sexual dysfunction, dry mouth, blurred vision, constipation Boxed Warning: ↑ suicide risk in youth Notes: CI with MAOI (≤14 days); taper off gradually |
| nortriptyline (PO) | Pamelor | Tricyclic antidepressant (TCA) | MDD, diabetic neuropathy, migraine prophylaxis | Side Effects: dizziness, drowsiness, low BP, sexual dysfunction, dry mouth, blurred vision, constipation Boxed Warning: ↑ suicide risk in youth Notes: CI with MAOI (≤14 days); taper off gradually |
| doxepin (PO) | Silenor | Tricyclic antidepressant (TCA) | Insomnia | Key Side Effects: somnolence, sedation, nausea US Boxed Warnings: increased risk of suicidal thinking and behavior in children, adolescents, and young adults Other Notes: CI within 14 days of MAOI; do not discontinue abruptly |
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