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PCOL PRE FINALS
Eicosanoids, Mild Analgesics, CNS Drugs, Antipsychotics
| Question | Answer |
|---|---|
| Which biochemical pathway of arachidonic acid will produce leukotrienes, HPETEs, and HETEs? | Lipoxygenase pathway |
| Which of the following is NOT the site of synthesis for leukotrienes, HPETEs, and HETEs? | White blood cells |
| What is the other term for prostaglandin H Synthase? | Cyclooxygenase |
| Which of the following is NOT a function of COX-1 enzyme? | Inflammation |
| Which of the dollowing eicosanoids has an analogue that is primary indicated cytoprotectant in PUD? | PGE-1 |
| It is approved for use in patients taking high doses of NSAIDs to reduce gastric ulceration? | Misoprostol |
| True concerning prostaglandins: I. Inhibits platelet aggregation II. Stimulates release of histamine III. Plays a vital role in inflammation IV. Produce under COX Pathway | II, III, and IV |
| Epigastric pain is caused by ibuprofen inhibiting? | COX-1 |
| What are large group autacoids with potent effects on virtually every tissue in the body derived from membrane phospholipids? | Eicosanoids |
| An enzyme that is produced by the body responsible for cytoprotectant action | COX-1 |
| Which of the following drugs would decrease the amount of asthma attacks by preventing an arachidonic acid derivative from its binding to its receptor? | Montelukast |
| Which of the following effects is caused by prostacyclin? | Vasodilation |
| Which of the following is an effect of thromboxane | Inhibit platelet aggregation |
| Which agent can be used as antidote for paracetamol poisoning | N-Acetylcysteine |
| NSAID which can replace opioids in some situation involving mild to moderate postsurgical pain? | Ketorolac |
| The pharmacologic activity of mefenamic acid: I. Analgesic II. Antinflamatory III. Antipyretic IV. Antiplatelet | I only |
| Which of the following medications that represent arthritis therapy least likely to cause gastric ulceration? | Piroxicam |
| Which of the following is a propionic acid derived NSAIDs? | Ibuprofen |
| Analgesic that is available as 2% oral ointment used to manage painful oral lesions? | Dilfunisal |
| Which enzyme is inhibited by NSAIDs? | Cyclooxygenase |
| Which dose of aspirin can elicit anti-inflammatory activity? | 80mg |
| It is prepared as topical gel for the management of solar ketoses? | Diclofenac |
| Effects of paracetamol | Analgesic and Antipyretic |
| Which analgesic is indicated to be used for the mgt. of patent ductus arteriosus? | Indomethacin |
| This agent used as analgesic is associated with pseudo-porphyria and photosensitivity | Naproxen |
| Which of the following is true about aspirin? I. Has antiplatelet activity II. increase GFR III. irreversibly block COX enzyme IV. Tinnitus when toxic | I, III, IV |
| Patients taking nonselective NSAIDs should periodically be screened for? | Nephrotoxicity |
| Whixh NSAID is used therapeutically after myocardial infarction to reduce blood clot? | Aspirin |
| CONTRAINDICATION: Paracetamol | Chronic Alcoholic |
| CLASSIFICATION: Paracetamol | P-aminophenol |
| CONTRAINDICATION: Aspirin | Viral infection in children |
| CONTRAINDICATION: Celecoxib | Coronary artery disease |
| CONTRAINDICATION: Morphine | Opioid addicts |
| CONTRAINDICATION: Naltrexone | Respiratory depression |
| Only NSAID that is marketed as single enantiomer | Naproxen |
| Indole derivative used for gingival and conjunctival inflammation | Indomethacin |
| Propionic Acid that has very long half life | Oxaprozin |
| Most useful in gout than any other NSAID | Oxaprozin |
| Effective in closing the PDA in preterm infants | Ibuprofen |
| Racemic acetic acid derivative | Etodolac |
| Induces uric acid stone formation | Tolmetin |
| Prolongs bleeding time as it's A/E | Aspirin |
| The only dermatologic A/E of Acetaminophen Clue: SJS | Steven-Johnson Syndrome |
| 1ST line agent for osteoarthritis | Acetaminophen |
| Used for dull pain, hyperpyrexia, and for viral infections in children | Acetaminophen |
| Unpleasant state of tension, apprehension, or uneasiness | Anxiety |
| Stimulates locus ceruleus firing and increase noradrenergic activity | Anxiogenic |
| Receptor that is hyperactive in some patients with panic disorder | Alpha 2 receptor |
| Inhibits locus ceruleus firing and decreasing noradrenergic activity | Anxiolytic |
| Has strong regulatory or inhibitory effect on 5HT and NE | GABA Receptor |
| Originates in raphe nuclei of the brain stem and projects diffusely in the brain Clue: 5HT | Serotonin |
| Recurrent episodes of brief overwhelming anxiety, usually occur without triggers | Panic Disorder |
| Chronic, free floating anxiety, and undue worry. Chronic in nature Clue: Always with GAD | Generalized Anxiety Disorder |
| Repetitive anxiety, repetitive behaviors triggering anxiety | Obsessive compulsive disorder |
| uncommonly diagnosed but fairly common condition which the px. experiences severe anxiety in social interactions | Social Anxiety Disorder |
| Manifested thru traumatic or life threatening events resulting to intrusive anxiety provoking thoughts. Clue: Remember | Post-traumatic Stress Disorder |
| Disorder or type of anxiety that has something to do with food | Eating Disorder |
| taking large amount of food then purging through emesis, laxatives, etc. | Bulimia |
| Reduced food intake, or appetite. This happens when a patient has morbid fear if gaining weight or body distortion | Anorexia |
| Could be Situational, Medical, Psychiatric, or Drug induced disorder that alters the patient's sleep pattern | Insomnia |
| Anxiolytic agent that reduces anxiety and exerts a calming effect | Sedatives |
| Anxiolytic agent that produces drowsiness and is used for maintenance of a state of sleep | Hypnotics |
| TRUE OR FALSE: Anxiolytic agents are lipophilic | True |
| Anxiolytic agents should cross the blood brain barrier, however it also crosses ____________ barrier that can enter the fetus. | Placenta barrier |
| This organ effect has decreased latency of sleep onset | Sedation and Hypnosis |
| This organ effect is useful for operations and surgeries especially on its third stage (excitement or aggressiveness of the px.) | Anesthesia |
| A sulfonamide that can cause rashes, has lesser GI Effect | COX-2 Inhibitors |
| Presence of delusions, various types of hallucinations, and grossly disorganized thoughts | Psychosis |
| Disease associated usual cause of psychosis | Systemic lupus erythematosus |
| Kind of psychosis that is a neurodevelopmental disorder, and is characterized mainly by a clear sensorium | Schizophrenia |
| Also known as overt symptoms that should not be present (Hallucinationsa, Delusions, Disorganized Thoughts) | Positive symptoms |
| This symptoms are lack of characteristics and does not refer to the person's attitude. | Negative symptoms |
| Negative symptom that refers to the loss of speech | Alogia |
| Person is very suspicious of others thinking they have grand scheme | Paranoid schizophrenia |
| Person is extremely withdrawn, negative, and isolated. | Catatonic schizophrenia |
| Person is verbally incoherent and inappropriate moods and emotions to their situation | Disorganized Schizophrenia |
| Person has no delusion, hallucination, or disorganized sppech and behavior but is lacking motivation. | Residual schizophrenia |
| schizophrenia that does not conform to any other subtypes | Undifferentiated schizophrenia |
| Person Has symptoms of schizophrenia, mood disorder, major depression, bipolar, mania | Schizoaffective disorder |
| Another name for antipsychotics (except for neuroleptics) | Major Tranquilizers |
Created by:
cesvl
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