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Endocrine 1

BDK

Pharmacologic CategoryGeneric NameBrand NameCommon IndicationEssential Knowledge
Biguanide metformin Fortamet, Glumetza Type 2 DM, PCOS KSE: diarrhea, nausea, vomiting, vitamin b12 deficiency. ON: CI with eGFR <30. BBW: lactic acidosis
Dipeptidyl peptidase (DPP-4) inhibitor sitagliptin Januvia, Zituvio Type 2 DM KSE: nasopharyngitis
Sodium-glucose cotransporter inhibitor 2 (SGLT2 inhibitor) empagliflozin Jardiance Type 2 DM, HF, CKD KSE: genital mycotic infections, UTI
Sulfonylurea glimepiride Amaryl Type 2 DM KSE: hypoglycemia, weight gain
Sulfonylurea glipizide Glucotrol, Glucotrol XL Type 2 DM KSE: hypoglycemia, weight gain
Thiazolidinedione (TZD) pioglitazone Actos Type 2 DM KSE: peripheral edema, weight gain, URI, increased risk of fractures and bladder cancer. BBW: may be exacerbate CHF and CI in NYHA Class III and IV
Glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide Victoza, Saxenda Type 2 DM, chronic weight management KSE: nausea, vomiting, diarrhea, pancreatitis. BBW: may increase risk of thyroid c-cell tumor, CI in personal or family history of medullary thyroid cancer
Insulin, long acting insulin glargine Lantus, Toujeo, Basaglar Type 1 & 2 DM KSE: hypoglycemia, weight gain
Insulin, intermediate acting insulin NPH Humulin N, Novolin N (OTC) Type 1 & 2 DM KSE: hypoglycemia, weight gain
Insulin, rapid acting insulin aspart Novolog Type 1 & 2 DM KSE: hypoglycemia, weight gain
Insulin, rapid acting insulin lispro Humalog Type 1 & 2 DM KSE: hypoglycemia, weight gain
Insulin, short acting insulin regular Humulin R, Novolin R Type 1 & 2 DM, DKA KSE: hypoglycemia, weight gain
Sodium-glucose cotransporter inhibitor 2 (SGLT2 inhibitor) dapagliflozin Farxiga Type 2 DM, HF, CKD KSE: genital mycotic infections, UTI
Glucagon-like peptide 1 (GLP-1) receptor agonist dulaglutide Trulicity Type 2 DM KSE: nausea, vomiting, diarrhea, constipation, pancreatitis. BBW: may increase risk of thyroid c-cell tumor
Glucagon-like peptide 1 (GLP-1) receptor agonist semaglutide SQ: Ozempic, Wegovy PO: Rybelsus Type 2 DM, chronic weight management KSE: nausea, vomiting, diarrhea, constipation, pancreatitis. BBW: may increase risk of thyroid c-cell tumor, CI in personal or family history of medullary thyroid cancer
Dual GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) agonist tirzepatide Mounjaro, Zepbound Type 2 DM, chronic weight management KSE: nausea, vomiting, diarrhea, constipation, increased heart rate, pancreatitis. BBW: may increase risk of thyroid c-cell tumor
Created by: TORICBC
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