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Musculoskeletal

BDK

Pharmacologic CategoryGeneric NameBrand NameCommon IndicationKey Side EffectsBBW/ON
Alpha 2 agonist tizanidine Zanaflex Spasticity drowsiness, hypotension, dizziness, xerostomia, weakness ---
Aminoquinolone hydroxychloroquine Plaquenil RA, SLE, malaria retinal toxicity, rash, diarrhea long-term cause cardiomyopathy, bone marrow suppression, QT prolongation, and neuromuscular effects
Antigout colchicine Colcyrs Gout N/V/D, bone marrow suppression, myopathy (including rhabdomyolysis ---
NSAID diclofenac Voltaren OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase risk of serious/fatal CV thrombotic events, MI, stroke, GI events ulceration, bleeding, perforation; ON: may reduce renal blood flow and compromise existing renal function
NSAID ibuprofen Motrin, Advil OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase risk of serious/fatal CV thrombotic events, MI, stroke, GI events ulceration, bleeding, perforation; ON: may reduce renal blood flow and compromise existing renal function
NSAID meloxicam Mobic OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase risk of serious/fatal CV thrombotic events, MI, stroke, GI events ulceration, bleeding, perforation; ON: may reduce renal blood flow and compromise existing renal function
NSAID idomethacin Indocin OA, RA, acute pain, gout diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase risk of serious/fatal CV thrombotic events, MI, stroke, GI events ulceration, bleeding, perforation; ON: may reduce renal blood flow and compromise existing renal function
NSAID naproxen Naprosyn, Anaprox, Aleve OA, RA, acute pain, gout diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase risk of serious/fatal CV thrombotic events, MI, stroke, GI events ulceration, bleeding, perforation; ON: may reduce renal blood flow and compromise existing renal function
NSAID ketorolac Toradol Pain diarrhea, dyspepsia, abdominal pain, flatulence, nausea indicated for short term use <5 days
NSAID, COX-2 selective celecoxib Celebrex OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, flatulence, nausea may increase risk of serious/fatal CV thrombotic events, MI, stroke, GI events ulceration, bleeding, perforation; ON: may reduce renal blood flow and compromise existing renal function
NSAID diclofenac Voltaren Gel OA pruritis, rash ---
Skeletal muscle relaxant cyclobenzaprine Flexerilm Amrix, Fexmid Muscle spasm drowsiness, dizziness, fatigue, xerostomia may cause prolonged cardiac arrhythmias, and tachycardia, CI w/in 14 days of MAOI therapy
Skeletal muscle relaxant baclofen --- Spasticity drowsiness ---
Skeletal muscle relaxant methocarbamol Robaxin Muscle spasm drowsiness ---
Transdermal: topical analgesic; IV: antiarrhythmic lidocaine Transdermal: Lidoderm; IV: Xylocaine Transdermal: pain; IV: ventricular arrhythmias transdermal: dermatitis, erythemia, urticaria, skin depigmentation, skin edema; IV: bradycardia patch may stay on for up to 12 hrs in any 24 hr period
Xanthine oxidase inhibitor allopurinol Zyloprim Gout N/D, rash, leukopenia, thrombocytopenia rare severe/fatal hypersensitivity syndrome (highest risk in certain Asian population)
Depolarizing neuromuscular blocking agent succinylcholine Anectine Neuromuscular blockade for intubation or procedures hyperkalemia, myalgia, malignant hyperthermia (rare) acute rhabdomyolysis and hyperkalemia leading to cardiac arrest and death in pediatric patients w/ undiagnosed skeletal muscle disease
Anti-tumor necrosis factor alpha inhibitor entanercept Enbrel RA infection, injection site rxn, headache, nausea serious infections, malignancies (lymphoma)
Anti-tumor necrosis factor alpha inhibitor adalimumab Humira RA, Crohn's Disease, Ulcerative Colitis infection, injection site rxn, headache, nausea serious infections, malignancies (lymphoma)
Created by: TORICBC
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