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Inhalants & GHB

Uni of Notts, Addiction & The Brain, first year

QuestionAnswer
Inhalants Any volatile substance (usually household items) that are vaporised & inhaled to enter the blood stream where it will cross the blood-brain barrier & act on the brain
Acute exposure Euphoria, light-headedness, feeling of body lightness, sedation, hallucinations, delusions, Sudden Sniffing Death Syndrome (SSDS)
Chronic exposure Not well documented but studies show lesions in white matter in the brain & subcortical matter in some important structures
Sir Humphry Davy Chemist who experimented with inhaling various substances (such as nitrous oxide) at parties with friends to document their experiences of the substances, this led inhalants to be used in medical & dental procedures
General neural mechanisms of inhalants Volatile lipophilic molecules can interact hydrophobically with receptor subunits: increasing stability & conductance of GABAa & D2 domains while destabilising interactions between NMDA receptor subunits
Created by: Beech47
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