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pharmacokinetics

chapter 4

QuestionAnswer
absorption process of moving a substance from it site of administration accross body membranes and circulating fluids
affinity parts of the body attracted to certain medications
blood-brain barrier a barrier that prevents many chemicals and medications from entering
conjugates addition of side chains during metabolism
distribution transport of pharmacologic agents throughout the body
drug protein complex drugs bind reversibly to plasma proteins
enterohepatic recirculation recycling of drugs and other substances of the bile thru the liver and intestine
enzyme induction some drugs having the ability to increase metabolic activity in the liver
excretion drug removed from the body
fetal-placental barrier placenta prevents chemicals and medication from entering.
first pass effect
hepatic microsomal enzyme system inactivate drugs and accelerate their excretion
loading dose highest amount of drug given once or twice in the initial stages of administering the drug
maintenance drugs given to keep the plasma drug concentration in therapeutic range
metabolism called "biotransformation" chemically converting a drug so that it more easily removed from the body.
minimum effective concentration amount of drug required to produce therapeutic affect
pharmacokinetics study of drug movement throughout the body
plasma half-life length of time it takes for the plasma concentration of a medication to decrease by one/half after administration
prodrug have no pharmacologic activity until they are metabolized to there active form by the body
therapeutic range plasma drug concentration between min. effective concentration and toxic concentration
toxic concentration amount of drug in the system that will produce severe adverse effects.
Created by: chynag1
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