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Pharmacology 1

Chapter 1,2,4,5

Pharmacologia sen Manducto First recorded reference to pharmacology written by Samuel Dale in 1693
Modern Pharmacology Began in early 1800's, chemists isolated pharmacological subsstances from natural substances, effecs on animals studied, and early researchers used themselves as test subjects
The Distinct Discipline First department of pharmacoloogy est. at Estonia in 1847
John Jacob Abel Father of American pharmacology, founder of pharmacology dept. at U of M in 1890
20th Century to Present Drugs synthesized in laboratory, tested for relatively short time, understandin increased of how they produce their effects, and focus is on improvements in quality of life
Pharmacology greek for study of medicine, encompasses how drugs are aministered, where drugs travel in the body, and responses drugs produce
Interrelated Subject Areas ANP, Chem, Micro, and pathophysiology
Characteristics of 10,000 drugs Therapeutic applications, interactions, side effects, mechanisms of action
Drugs elicit different responses depending on age, sex, body mass, health status, genetics
Therapeutics concerned with the prevention of disease and treatment of suffering
pharmacotherapy the application of drugs for disease prevention and treatment of suffering
chemical drugs synthesized in a laboratory
medication a drug that is administered produce biological responses
therapeutic response a desirable response in the body
adverse response an undesirable response in the body
biologics agents naturally produced in animal cells, by microorganisms, or by the body itself
examples of biologics hormones, monoclonal antibodies, natural blood products and components, interferon, and vaccines
Complementary and Alternative Therapies Natural plant extracts, herbs, vitamins, minerals, dietary supplements, acupuncture, biofeedback
OTC advantages economical, no health-care appt.
OTC disadvantages may choose wrong drug, client my not know reactions or interactions, and innefective treatment may result in progression of disease
prescription drugs require that the recipient obtain a written order from a person with the legal authority to write such a prescription
prescription drug advantages health care provider examines the client and orders proper drug, amt and freq is controlled, instructions and on use side effects of drug are discussed
prescription drug disadvantages requires a prescription to obtain, need for health care provider
formulary the first standard list of drugs and drug recipes commonly used by pharmacists
pharmacopoeia a medical reference summarizing standards of a medical reference summarizing standars of drug purity, strength, and directions for synthesis
United States Pharmacopoeia(USP) first comprehensive publication of drug standards of purity, strength, directions for synthesis US 1820
American Pharmaceutical Organization (APhA) National professional society of pharmacists 1852, maintained the national compendia of drug standards, the National Formulary (NF)
National Formulary (NF) national compendia of drug standard, competed with other compendia (USP)
USP-NF merged in 1975, offical monographs and interim announcements published regularly, full bound version printed every five years
Biologic Control Act of 1902 standardized serum and blood-related products
Pure food and Drug Act of 1906 government controls labeling of medicines
Sherley Amendment of 1912 prohibited drugs labeled with false therapeutic claims
Food, Drug, and Cosmetic Act of 1938 and amenments thorough testing of drug, prood of safety and efficacy of drug
Dietary Supplement Health and Education Act of 1994 controls misleading industry claims
Food and Drug Adminstration (FDA) Agency of US department of health and human services in 1988
Created by: hmoore37



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