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Drugs for Pep ulcers

TermDefinition
Names of H2 receptors blockers Cimetidine Ranitidine Famotidine Roxatidine Loxatidine Tiotidine Nizatidine Oxmetidine
Actions of H2 receptor blockers Decrease intrinsic factors, pepsin, and gastric acid Attenuate fall in BP due to histamine Block histamine induced cardiac stimulation, uterine relaxation, bronchial relaxation.
Effects of Cimetidine Increases plasma prolactin Decreases estrogen metabolism Displaces dihydrotestosterone from its receptors
Long term effects of Cimetidine Gynecomastia, low libido, impotence and temp oligospermia
Common A/E of Cimetidine Myalgia Skin rashes Itching Confusion Restlessness Hallucinations Delirium Convulsions Coma-Elderly
Names of Proton pump inhibitors Omeprazole Lansaprazole Pantoprazole Rabeprazole Esomeprazole
MOA of Omeprazole Two charged cationic forms; Suphenic acid & sulphenamide react covalently with the SH groups of the H+/K+ATPase - irreversible inactivation
Common A/E of Proton pump inhibitors Modest hypergastrinemia Diarrhoea Abdominal pain. Skin rashes Leukopenia. Potential risk-bacterial overgrowth & Nosocomial pneumonia.
Use for Pr
Names of Ulcer protective drugs Sucralfate Colloidal bismuth subcitrate(CBS)
Common A/E of Sucralfate Constipation Dry mouth Hypophosphatemia Rashes Pruritus
Uses for Sucralfate Duodenal ulcer Gastric ulcer Reflux oesophagitis Gastritis Bile reflux Phosphate stones in the kidney Stomatitis
Created by: Jameel D. Wilson
Popular Pharmacology sets

 

 



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