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CNS 3 Spears/Sikazwe
Anxiety disorders
| Term | Definition |
|---|---|
| What are the 2 cognitive centers of the brain | prefrontal cortex; orbitofrontal cortex |
| What is the emotional center of the brain | Limbic (hippocampus/HPA/Amygdala) |
| What part of the brain that is involved in executive function and cognitive control? | prefrontal cortex |
| what part of the brain is involved in judgemental and decision making | orbitofrontal cortex |
| what is the NT imbalance that causes anxiety | increase in glutamate; decrease in GAB, 5-HT, and NE (so this NT imbalance along with the environment and genetics contribute to anxiety |
| what drug classes are used for long term tax of anxiety | SSRI; SNRI; atypicals, TCAs, MAOIs |
| what drug class us used for rapid relief and for tolerance and dependence | BZD |
| what is the antidote for BZDs | Flumazenil |
| what drug classes is used for short-term relieve and acute panic attacks? | beta blockers |
| what are all meds for anxiety disorders trying to do? | prevent and treat anxiety |
| What is the first line and maintenance therapy? | SSRIs (first line) SNRIs (especially venlafaxine bc it lasts longer |
| does duloxetine have more SERT or NET blockade/affinty | neither; equal affinity, blockade of SERT and NET |
| Does venlafaxine have more SERT or NET blockade/affinity | SERT |
| Does milnacipran have more SERT or NET blockade/affinity? | NET |
| What drug class has the fastest onset for acute attack? | BZDs |
| are BZDs used as first lone or adjuvant therapy? | adjuvant therapy |
| what are BZDs used for? | acute panic attacks |
| what site do BZDs activate only? | BZDs only activate GABA-A; add increase CL- into the neuron; they do not activate GABA-B; remember GABA-A: is ionotropic , ligand gated Cl- channel with fast conductance; GABA-B; metabotropic, GPCR and is slow-acting |
| what drug classes is this? Positive allosteric; modulators og GABA-A receptors; ionitrophic, chloride channel | BZDs |
| T/F: GABA and BZDs have different sites what does the GABA site bind to What do BZDs bind to? The anxiolytic effect of BZDs are driven by expression of what? | true the beta-alpha subunit The alpha-gamma subunits Alpha-2 and alpha-3 -anxiolytics need alpha-2 and alpha-3 expression for anxiety reducing effects |
Created by:
Xander635
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