Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Amiodarone
Antiarrhythmic Drug - Intern Revision
| Question | Answer |
|---|---|
| What antiarrythmic class of drug is amiodarone? | Class 3 |
| What are the recommendations for use of amiodarone in pregnancy? | Not recommended to use 3 months prior to conceiving and all through the pregnancy |
| The TGA has given which pregnancy classification to amiodarone? | Category C |
| What are the possible impacts on the fetus if amiodarone is used during pregnancy? | Severe bradycardia and thyroid dysfunction |
| Is amiodarone safe to use in breastfeeding? | No |
| List the indications for amiodarone | Treat + prevent recurring arrhythmias including supra/ventricular and ventricular tachycardias (AF, A flutter, WPWS, nodal etc) |
| What is the oral adult loading dose for amiodarone? | 200mg tds for 1 week reducing to 200mg bd for 1 week |
| What is the oral adult maintenance dose for amiodarone? | 100-200mg once daily |
| Explain the MOA of amiodarone | Reduced response to unwanted electrical activity by prolonging action potential duration and refractory period of all cardiac tissue. Result = directly reduces cardiac tissue excitability and prevents conduction of unwanted electrical signals. |
| Discuss the precautions and contraindications to amiodarone | C/I: allergy to iodine, heart block, sick sinus syndrome, symptomatic bradycardia P/C: poor liver + lung function, elderly, uncontrolled thyroid function, poor vision Screening: LFT, eye tests, lung function, ECG, thyroid |
| What are the key side effects associated with amiodarone? | Alopecia, corneal deposits, optic nephropathy, hypo/hperthyroidism, pulomary toxicity (SOB, dry cough), bradycardia, worsening of arrythmia, hepatotoxicity, photosensitivity |
| What is a patient being monitored for whilst using amiodarone? | Every 6 months: ECG, chest X-ray, LFT, lung function test, eye test, thyroid test, electrolytes, worsening of arrhythmia, BP, HR. Commencement of any other medications (RX or OTC) Other comorbidities: diabetes, obesity, HTN, Heart disease etc |
| List some medications that amiodarone can interact with | Simvastatin, digoxin, warfarin, dabigatran, metoprolol, phenytoin, rifampicin + many more! |
| What are some counselling points to discuss with someone starting on amiodarone for the first time? | Avoid sun exposure (8) Avoid grapefruit juice (18) Advise all health professionals you are taking this medication Need for regular health check ups (ECG, LFT etc) Ask Dr/Pharm before starting any new medication |
| What are the referral points for amiodarone? | SOB, dry cough, blurred vision/visual disturbances, weight loss, muscle weakness, worsening arrhythmia, signs and symptoms of hypo/hyperthyroidism |
| What is the onset of action for amiodarone? | 2 days to 3 weeks due to slow and variable oral absorption |
Created by:
LDM
Popular Pharmacology sets