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Neuromuscule
Neuromuscular blocking drugs
| Question | Answer |
|---|---|
| What are the two options for Nm blockade? | non-depolarizing (keeps Na channel closed) or depolarizing (keeps Na channel open for paralysis) |
| What is the classic non-depolarizing Nm blockade? | D-tubocurarine |
| What is the classic depol blockade? | Succinylcholine |
| 2 part phase for depolarizing using Succinylcholine? | Phase 1 is opening, initial contraction and long term paralysis Phase 2 is repolarizing and may have damaged the channels |
| Side effects of overdose of ganglionic blockers? | intraocular and intrgastric pressure, muscle pain, hyperkalemia (from contraction), and hypotension (histamine or ganglionic blockade) |