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Autonomic Pharm III

Indirect Acting Cholinomimetics

QuestionAnswer
What are the 5 main indirect acting cholinomimetics? Edrophonium, Physostigmine, Neostigmine/pyridostigmine, Donepezil/Tacrine, Organophosphates
What is Edrophonium's characteristic? Clinical use? short acting; DX of myasthenia and used for Myasthenia
What is physostigmine's characteristic? Clinical use? Tertiary amine that enters CNS and acts immediately; Rx for glaucoma and antecdote to atropine
Neostigmine and Pyridostigmine characteristics? Clinical use? Quarternary amines (NO CNS); RX for ileus, urinary retention, myasthenia, and reversal of non-depolarizing NM blockers
Donepezil and Tacrine characteristics? Clinical use? Lipid soluble (CNS entry); Alzheimer's
Organophosphate characteristics? Clinical uses? lipid soluble, long lasting, and irreversible AchE inhibitors; RX for glaucoma (TOPICAL) and used in insecticides (POISONINGS)
Created by: cpeluso
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