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Chapter 2 - Pharm
| Front | Back |
|---|---|
| Low Dose-Effect Curve | Measuring the response to the dose of the drug |
| Potency | The amount of drug required to produce an effect. |
| Efficacy | Related to the maximal effect of a drug regardless of dose |
| Therapeutic action | The intended or desired results |
| Therapeutic range | Range between the dose causing the minimum effect and the dose causing the minimum adverse effect. |
| Therapeutic index (TI) | Number that determines the safety of a drug. (the greater the TI, the safer the drug) |
| Hepatic | Liver |
| Biotransformation | Is the body’s way of changing a drug so that it can be more easily excreted by the kidneys |
| Tolerance | The need for an increasingly larger dose of the drug to obtain the same effects as the original dose |
| Renal | Kidney |
| Duration | The length of a drug’s effect |
| Half-Life | The amount of time that passes for its concentration to fall to half (50%) of its original blood level |
| Two functions of drugs | Enhance or inhibit body function |
| Antagonist | Inhibit normal functions |
| Agonist | Enhance normal functions |
| 4 major steps that influence the movement of a drug | • Absorption • Distribution • Metabolism • Elimination (Excretion) |
| 3 major routes of drug administration | Enteral, Parental, Topical |
| Enteral | uses the GI tract: Safest, slowest and most variable route |
| Parental | Administered or occurring elsewhere in the body other than the mouth and alimentary canal. Drugs bypass the GI tract. |
| Topical | Drug is applied to the body surface and absorbed slowly by capillaries under the skin. |
Created by:
d.hovey
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