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Histamine

QuestionAnswer
Contraindications of histamine Bronchial asthma Active peptic ulcer Pheochromocytoma
What is used to Tx Meneire’s disease? Betahistine
Betahistine It is analogue of histamine and acts on H1 receptor
Histamine is synthesized by 2 enzymes Histidine de-carboxylase that converts histidine to histamine. This enzyme is inhibited by methyl histidine. - Aromatic amino acid de-carboxylase which is non specific enzyme and inhibited by methyl-dopamine .
Pharmacological actions of H1 blockers anti-nausea and anti-emetic Anti-cholinergic effect Local anesthetic effect. Anti- parkinsonism effect. Antiserotoninergic effect α- adrenoceptor blocking effects. they inhibit P-glycoprotein
1st generation H1-blockers General properties Great CNS depression Relatively of short duration of action. Relatively of little dangerous drug interaction with macrolides antibiotics and antifungal drugs. Blockage of muscarinic receptor
Names of 1st generation H1-blockers Diphenhydramine Dimenhydrinate Promethazine Hydroxyzine Cyproheptadine Meclizine Pheniramine Cinnarizine Buclizine Chlorpheniramine Cyclizine Clemastine Triprolidine Demethindene
Contraindications of H1 blockers Hypersensitivity to the drugs. Severe bronchial asthma. Prostatic hyperplasia. Closed angle glaucoma. Bladder neck obstruction. Breast feeding.
Created by: Jameel D. Wilson
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