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MS ADRs
adverse drug reactions of musculoskeletal meds
| Question | Answer |
|---|---|
| methotrexate | -increased infection risk -hepatic toxicity -bone marrow suppression -ulcerative stomatitis |
| etanercept | -nausea, stomatitis, alopecia -flu symptoms -infectious diseases (TB) -skin irritation |
| tofacitinib | -infection -cancer -blood clots -stomach or intestine tears -allergic reactions -abnormal blood tests |
| raloxifene | -thrombosis -hot flashes -leg cramp -edema of hands, feet, ankles -joint pain -flu-like symptoms |
| alendronate | -heartburn -difficulty swallowing -severe joint, bone, muscle pain -low calcium levels |
| denosumab | -severe allergic reaction -hypocalcemia -severe joint, muscle, bone pain -skin problems -infections -osteonecrosis of the jaw -weakness -femur fractures |
| teriparatide | -hypercalcemia -joint pain -toxicity |
| calcitonin-salmon | -antibody formation -hypocalcemia -malignancies -flushing |
| calcium citrate | -minimal or no urination -swelling; rapid weight gain -hypercalcemia |
| colchicine | -GI symptoms |
| probenecid | -hematuria -nephrotic syndrome -hepatic necrosis |
| allopurinol | -kidney and liver damage -thrombocytopenia -gout flare-up -skin reactions |