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MS Actions

Musculoskeletal Pharmacologic Actions

QuestionAnswer
allopurinol reduces the production of uric acid in the body
colchicine interferes with intracellular assembly of the inflammation-some complex present in neutrophils and monocytes that mediates activation of interleukin-1B
probenecid inhibits reabsorption of uric acid at the proximal convoluted tubule, increases plasma levels of weak organic acids by competitively inhibiting their renal tubular secretion
methotrexate slow joint degeneration and progression of RA
etanercept binds with naturally occurring tumor necrosis factor, preventing it from attaching to cells on the surface of synovial tissue in the joints
tofacitinib suppresses the immune system
raloxifene activates estrogen receptors in the bones to build and maintain strong bones
alendronate inhibits osteoclasts
denosumab binds receptor activator of nuclear factor kappa-B ligand to decrease ability of osteocytes to produce and activate osteoclast
teriparatide mimics effects of parathyroid hormone
calcitonin-salmon acts similar to calcitonin produced by thyroid gland by inhibiting action of osteoclasts and increases excretion of calcium
calcium citrate provides more calcium to body
Created by: mbaldwin13
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