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RHEUMATOID ARTHRITIS

TermDefinition
TREATMENT OF RHEUMATOID ARTHRITIS (symptomatics) Nonsteroidal anti inflammatory drugs (NSAIDs).
Names of NSAIDs for RA. Aspirin Indomethacin Ibuprofen Naproxen Piroxicam Nabumetone Diclofenac
Disease Modifying antirheumatic Drugs ( non-biological) 1. Sulfasalazine 2. Methotrexate 3. Azathioprine 4. Chloroquine or Hydroxychloroquine 5. Cyclosporine 6. Leflunomide
Chloroquine (MOA, ADR) MOA: Suppress T-lymphocyte responses to mitogens. Adverse Effects: Retinopathy and Corneal opacity.
Sulfasalazine (MOA, ADR) MOA: Sulfasalazine is metabolized to sulfapyridine and 5-aminosalicylic acid. Then inhibit inflammatory cytokine production, that is, IL-1, -6, -12, and TNF-α. ADR: Reversible infertility in men and Sulfa allergy (urticaria)
Methotrexate (MOA, ADR) MOA: antifolate antimetabolite that inhibits the enzyme dihydrofolate reductase (DHFR). DHFR converts dihydrofolate (DHF) to tetrahydrofolate (THF) ADR: stomatitis, liver enzyme elevations Contra: Pregnancy, mutations in cytochrome P450,
Disease Modifying antirheumatic Drugs (biological) TNF - Etanercept, Infliximab, Adalimumab IL-1 --> Anakinra
Created by: Jameel D. Wilson
Popular Pharmacology sets

 

 



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