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PCOL Exam 2 Drugs

PCOL Exam 2

DrugMOASOASide Effects / ADRsExtra / Key Information
Acetylcholine Nicotinic and Muscarinic Agonist All over body DUMBBELSS
Varenicline (Chantix) Nicotinic Partial Agonist CNS (Nn) Headache, Insomnia, Suicidal thoughts, Depression, N/V
Succinylcholine Neuromuscular Blockade (Keeps ion channels open) NMJ (Nm) *Can effect PNS and SNS NMJ Paralysis Hyperkalemia, HTN, Arrhythmias, Muscle pain, Hyperthermia Phase I: Binds to Ach binding space and keeps Na+ channels open Phase II: Blocks Na+ channels completely
Phyostigmine AChE Antagonist CNS & Periphery DUMBBELSS *Crosses BBB Treatment for anti-muscarinic poisoning (Atropine)
Donepizil, Rivastigmine, Galantamine AChE Antagonist CNS & Periphery DUMBBELSS *Crosses BBB Used for dementia and Alzheimers
Pyridostigmine, Neostigmine AChE Antagonist NMJ DUMBELS *Does NOT cross BBB Reverses effects of curare Treatment of myasthenia gravis
Edrophonium AChE Antagonist NMJ DUMBELS Diagnosis of myasthenia gravis
Echothiophate Organophosphate inhibitor of AChE M3 receptor in eye Miosis, Blurred vision, Lacrimation, Stinging/Redness of eye Glaucoma treatment
Botox Prevents ACh release Presynaptic terminal Muscle relaxation Cleaves sites on SNARE proteins
Curare-like drugs (Mivacurium, Vecuronium, Rocuronium, Pancuronium, Tubocurarine) Direct Competitive Antagonist NMJ NMJ Paralysis Histamine release, Hypotension, Tachycardia Does not allow Ach to bind
Acetylcholine Non-Selective Muscarinic Agonist (M1, M2, M3) CNS & Periphery DUMBBELSS
Methacholine Non-Selective Muscarinic Agonist (M1, M2, M3) CNS & Periphery DUMBBELSS
Carbachol Non-Selective Muscarinic Agonist (M1, M2, M3) CNS & Periphery DUMBBELSS
Bethanechol Non-Selective Muscarinic Agonist (M1, M2, M3) CNS & Periphery DUMBBELSS
Pilocarpine Non-Selective Muscarinic Agonist (M1, M2, M3) CNS & Periphery DUMBBELSS
Cevimeline Non-Selective Muscarinic Agonist (M1, M2, M3) CNS & Periphery DUMBBELSS
Atropine Muscarinic Antagonist (M1, M2, M3) CNS & Periphery Anti-DUMBBELSS Treatment of organophosphate poisoning; Treatment of muscarinic agonist overdose
Scopolamine Muscarinic Antagonist (M1, M2, M3) CNS Anti-DUMBBELSS (Anti-Emesis) For motion sickness
Benztropine Muscarinic Antagonist (M1, M2, M3) CNS (Parkinsons) Anti-DUMBBELSS
Tropicamide Muscarinic Antagonist (M1, M2, M3) Eyes (Dilation) Anti-DUMBBELSS
Ipratropium Muscarinic Antagonist (M1, M2, M3) Lungs Anti-DUMBBELSS
Tiotropium Muscarinic Antagonist (M1, M2, M3) Lungs Anti-DUMBBELSS
Aclinidium Umeclinidium Muscarinic Antagonist (M1, M2, M3) Lungs Anti-DUMBBELSS
Oxybutynin Muscarinic Antagonist (Mainly M1, M3) Bladder Anti-DUMBBELSS Least selective
Tolterodine Fesoterodine Muscarinic Antagonist (Mainly M3) Bladder Anti-DUMBBELSS
Solifenacin Darifenacin Trospium Muscarinic Antagonist (Mainly M3) Bladder Anti-DUMBBELSS Most selective
Nitryoglycerin Nitroprusside Isosboride dinitrate Nitric Oxide donors; Increase gCMP Blood Vessels Vasodilation, Lower BP
Sildenafil Tadalafil Vardenafil PDE Inhibitor; Increase cAMP levels Blood Vessels Vasodilation, Lower BP Used to treat ED
Phenylephrine a1 Agonist Blood Vessels, Eyes HTN, Burning and nasal discharge, Rebound congestion Avoid in patients with HTN
Cocaine NE Reuptake Inhibitor CNS HTN, Tachycardia, Arrhytmias, Restlessness
Amphetamines (Dextroamphetamine, Methylphenidate, Lisdexamfetamine, Dexmethylphenidate) Stimulate release of NE and DA CNS HTN, Tachycardia, Arrhytmias, Restlessness, Loss of appetite
Phenelzine MAO-A & MAO-B Antagonist CNS HTN, Tachycardia, Arrhytmias. Restlessness
Selegiline Rasagiline MAO-B Antagonist CNS HTN, Tachycardia, Arrhytmias. Restlessness
Prazosin Terazosin Doxazosin Tamsulosin a1 Antagonist Brain, Eye, Nose, Blood Vessels, Urethra Headache, Blurred vision, Orthostatic hypotension
Phenoxybenzamine a1 and a2 Antagonist Brain, Eye, Nose, Blood Vessels, Urethra, GI Headache, Blurred vision, Orthostatic hypotension, GI stimulation
Mirtazapine a1, a2, Muscarinic Antagonist CNS Drowsiness, Weight gain, Increased cholesterol, Constipation Used for MDD
Clonidine Brimonidine Tizanidine Guanfacune Dexmedetomidine a2 Agonist CNS Sedation, Dry mouth, Hypotension, Bradycardia, Sexual dysfunction, Depression, Constipation
Dobutamine B1 Agonist Heart, Kidneys, Brain Increased HR, Tachycardia, Arrhytmias
Metoprolol Atenolol Nebivolol Selective B1 Antagonist Heart, Kidneys, Brain Decreased HR, Fatigue, Dizziness, Bradycardia
Albuterol Levalbuterol Salmeterol Formoterol B2 Agonist Lungs Bronchial dilation
Propranolol Pindolol Timolol Non-Selective Beta Blocker Heart, Kidneys, Brain, Lungs, Vasculature Decreased HR, Fatigue, Dizziness, Bradycardia
Carvedilol Labetalol B1 and B2 Antagonist a1 Antagonist Heart, Kidneys, Brain, Lungs, Vasculature Decreased HR, Fatigue, Dizziness, Bradycardia
Mirabegron B3 Agonist Bladder Relief for overactive bladder
Epinephrine B1, B2 Agonist Heart and Vasculature SNS Activation
Norepinephrine a1, B1 Agonist Heart and Vasculature Increase TPR, HR
Isoproterenol B1, B2 Agonist Heart and Lungs Hyperglycemia, Palpitations, Tachycardia, Arrhytmias
Aliskiren Renin Inhibitor Blood stream Lower TPR, Aldosterone, Na+ and H2O Andiodema, Hypotension, Cough, Headache, Diarrhea
Catopril Enalapril Lisinopril Benazepril Quinapril Ramipril ACE Inhibitors Blood stream Lower TPR, Aldosterone, Na+ and H2O Dry cough, Hyperkalemia, "First dose" Hypotenison
Losartan Valsartan Olmesartan Telmisartan Irbesartan ARB (Ang II Receptor Blocker) Blood stream Lower TPR, Aldosterone, Na+ and H2O Hyperkalemia, Angioedema High affinity for AT1
Spironolactone Eplerenone Potassium-Sparing Diuretic Kidney Hyperkalemia, Diarrhea, Drowsiness
Metoprolol Selective B1 Blocker Kidney Less renin production No RAAS Pathway
Created by: merandaharker
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