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Pharmacology Exam 2

Cholinergic

QuestionAnswer
Acetylcholine MOA Methacholine Carbachol Bethanechol Non-selective Muscarinic Agonist (M1, M2, M3)
Acetylcholine SOA Methacholine Carbachol Bethanechol Central and periphery
Acetylcholine SE Methacholine Carbachol Bethanechol DUMBBELSS
Pilocarpine MOA Cevimeline Non-selective Muscarinic Agonist (M1, M2, M3)
Pilocarpine SOA Cevimeline Central and periphery
Pilocarpine SE Cevimeline DUMBBELSS
Pilocarpine EI Cevimeline Treatment of dry mouth (enhance salivation) / glaucoma
Atropine MOA Non-selective Muscarinic Antagonist (M1, M2, M3) Muscarinic Antagonist = “Anti-cholinergic”
Atropine SOA Central and periphery
Atropine SE Anti-DUMBBELSS Tachycardia, mydriasis, constipation, dry mouth, bronchial dilation, drowsiness
Atropine EI Treatment of organophosphate poisoning (severe DUMBBELSS) Treatment of muscarinic agonist overdose
Scopolamine MOA Non-selective Muscarinic Antagonist (M1, M2, M3)
Scopolamine SOA CNS – Penetrate CNS more rapidly
Scopolamine SE Anti-DUMBBELSS (anti-emesis)
Scopolamine EI Used to treat motion sickness
Benztropine (Cogentin) MOA Non-selective Muscarinic Antagonist (M1, M2, M3)
Benztropine (Cogentin) SOA CNS
Benztropine (Cogentin) SE Anti-DUMBBELSS
Benztropine (Cogentin) EI Used to treat Parkinson’s
Tropicamide MOA Muscarinic Antagonist
Tropicamide SOA Eyes
Tropicamide SE Anti-DUMBBELSS
Tropicamide EI Used for pupil dilation (block M3)
Ipratropium (Atrovent) MOA Non-selective Muscarinic Antagonist (M1, M2, M3)
Ipratropium (Atrovent) SOA Lungs
Ipratropium (Atrovent) SE Anti-DUMBBELSS
Ipratropium (Atrovent) EI Short-acting muscarinic antagonist (SAMA)
Tiotropium (Spiriva) MOA SELECTIVE Muscarinic Antagonist (M1 & M3)
Tiotropium (Spiriva) SOA Lungs
Tiotropium (Spiriva) SE Anti-DUMBELSS Heart rate not affected because it does not target M2
Tiotropium (Spiriva) EI Long-acting muscarinic antagonist (LAMA)
Aclidinium MOA Umeclidinium Muscarinic Antagonist
Aclidinium SOA Umeclidinium Lungs
Aclidinium SE Umeclidinium Anti-DUMBBELSS
Aclidinium EI Umeclidinium Long-acting muscarinic antagonist (LAMA)
Oxybutynin (Ditropan) MOA Tolterodine (Detrol) Fesoterodine (Toviaz) Solifenacin (Vesicare) Darifenacin Trospium Non-selective Muscarinic antagonist (M1, M2, M3) All are more selective for M3
Oxybutynin (Ditropan) SOA Tolterodine (Detrol) Fesoterodine (Toviaz) Solifenacin (Vesicare) Darifenacin Trospium M3 in Bladder
Oxybutynin (Ditropan) SE Tolterodine (Detrol) Fesoterodine (Toviaz) Solifenacin (Vesicare) Darifenacin Trospium All have potential to cause Anti-DUMBbELSs Xerostomia and constipation (M3)
Oxybutynin (Ditropan) EI Tolterodine (Detrol) Fesoterodine (Toviaz) Solifenacin (Vesicare) Darifenacin Trospium Solifenacin, Darifenacin, and Trospium are Most selective for M3 - least likely to cause anti-DUMBbELSS Used to treat overactive bladder
Nitroglycerine MOA Nitroprusside Isosorbide di / mononitrate Donate nitric oxide NO -> sGC-> increased cGMP
Nitroglycerine SOA Nitroprusside Isosorbide di / mononitrate Endothelium of blood vessels (M3)
Nitroglycerine SE Nitroprusside Isosorbide di / mononitrate Vasodilation Lower blood pressure
Nitroglycerine EI Nitroprusside Isosorbide di / mononitrate cGMP is a potent vasodilator
Sildenafil (Viagra) MOA Tadalafil (Cialis) Vardenafil Blocks PDE -> increase cGMP
Sildenafil (Viagra) SOA Tadalafil (Cialis) Vardenafil Endothelium of blood vessels (M3)
Sildenafil (Viagra) SE Tadalafil (Cialis) Vardenafil Vasodilation Lower blood pressure
Sildenafil (Viagra) EI Tadalafil (Cialis) Vardenafil Blocks enzyme that breaks down cGMP = more cGMP Used to treat erectile dysfunction
Created by: jflaman
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