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Pharmacology Exam 2

Neuromuscular

QuestionAnswer
Acetylcholine MOA Nicotinic & Muscarinic Depolarizing agent
Acetylcholine SOA All over the body
Acetylcholine Side effects DUMBBELSS
Varenicline (Chantix) MOA α4/β2 Nn partial agonis
Varenicline (Chantix) SOA CNS (Nn)
Varenicline (Chantix) side effects Headache, insomnia, suicidal thoughts, depression, flatulence
Varenicline (Chantix) extra info FDA warning of mood and behavioral changes; used for smoking cessation
Succinylcholine MOA Depolarizing agent (Neuromuscular blockade – nicotinic)
Succinylcholine SOA NMJ (Nm) Can affect autonomic (PNS / SNS) ganglia
Succinylcholine side effects NMJ Paralysis Hyperkalemia, HTN & arrhythmias, muscle pain (myalgia), hyperthermia
Succinylcholine extra info Phase 1: binds to Ach binding space and keeps all Na+ channels open (cannot repolarize) Phase 2: blocks Na+ channels (cannot depolarize)
Physostigmine MOA Cholinesterase Inhibitor (AChE Antagonist)
Physostigmine SOA CNS & periphery
Physostigmine SE DUMBBELSS
Physostigmine EI Penetrates CNS / cross BBB Treatment for anti-muscarinic poisoning (Atropine)
Donepezil (Aricept) MOA Rivastigmine (Exelon) Galantamine Cholinesterase Inhibitor (AChE Antagonist)
Donepezil (Aricept) SOA Rivastigmine (Exelon) Galantamine CNS & periphery
Donepezil (Aricept) SE Rivastigmine (Exelon) Galantamine DUMBBELSS
Donepezil (Aricept) EI Rivastigmine (Exelon) Galantamine Lipophilic - cross BBB Used for dementia / Alzheimer’s Longer t1/2 than Physostigmine
PyriDOstigmine MOA Neostigmine Cholinesterase Inhibitor (AChE Antagonist)
PyriDOstigmine SOA Neostigmine NMJ
PyriDOstigmine SE Neostigmine DUMBBELS No CNS effects
PyriDOstigmine EI Neostigmine DO NOT cross BBB Reverse the effects of Curare / treatment of myasthenia gravis
Edrophonium MOA Cholinesterase Inhibitor (AChE Antagonist)
Edrophonium SOA NMJ
Edrophonium SE DUMBBELS No CNS effects
Edrophonium EI Used for diagnosis of myasthenia gravis or medication dose adjustments Short duration of action/reversible
Echothiophate MOA Organophosphate inhibitor of acetylcholinesterase enzyme
Echothiophate SOA M3 receptor in ciliary muscle (eye)
Echothiophate SE Miosis and blurred vision, lacrimation, stinging / redness of eye
Echothiophate EI Ophthalmology treatment glaucoma
Botulinum Toxin (Botox) MOA Prevent ACh release
Botulinum Toxin (Botox) SOA Presynaptic terminal
Botulinum Toxin (Botox) SE Muscle relaxation
Botulinum Toxin (Botox) EI Cleaves sites on SNARE protein
Curare & Curare like MOA Mivacurium Vecuronium Rocuronium Pancuronium Tubocurarine NON-depolarizing agent Direct competitive antagonist  Binds to Ach binding space
Curare & Curare like SOA Mivacurium Vecuronium Rocuronium Pancuronium Tubocurarine NMJ
Curare & Curare like SE Mivacurium Vecuronium Rocuronium Pancuronium Tubocurarine NMJ Paralysis Histamine release, hypotension & tachycardia No CNS effect
Curare & Curare like EI Mivacurium Vecuronium Rocuronium Pancuronium Tubocurarine Doesn’t allow Ach to bind; Ach is required for muscle contraction
Created by: jflaman
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