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Psychopharm2

Random questions relating to psychopharm

QuestionAnswerBrand Names
carbidopa decarboxylase inhibitor
levodopa vit B increases peripheral breakdown and diminishes effectiveness
dont use levodopa in patients ____ with glaucoma
patients with glaucoma Levodopa, Benzos
drug-drug interactions levodopa and MAOI --> hypertensive crisis
antipsychotic drug contraindicated parkinsonian patients. sometimes atypicals can be used.
selegiline metabolized into amphetamine = insomnia if taken later than noon
rasagiline 5x more potent than Selegiline without the amphetamine side effects
levodopa-carbidopa side effects diarrhea, postural hypotension, nausea, anorexia, dyskinesia, hallucination, sleep d/o
amantadine antiparkinson. increase release of DA, black cholinergic receptors, inhibits NMDA
alzheimer's treatment 4 AChE inhibitor usually also give memantine
benzos temporarily impair memory
benzos have addiction potential recommend: clonazepam (Klonopin), lorazepam (Ativan), diazepam (Valium)
tx for panic disorder alprazolam Xanax
Treatment of muscle spams, MS, and cerebral palsy Diazepam Valium
epilespy treatment Clonazepam Klonopin
grand mal epileptic seisures and status epilepticus diazepam (Valium) and lorazepam (Ativan)
benzo for sleep: reduce sleep induction time and # of awakenings Flurazepam Dalmane
benzo for sleep: frequent wakening Temazepam Restoril
benzo for sleep: difficulty going to sleep Triazolam Halcion
benzos contraindicated liver disease, acute narrow angle glaucoma
Buspirone Buspar 5HT1a: GAD tx. some affinity for 5HT2a and DA. no anticonvulsant or muscle relaxant properties so minimal sedation
metablized by CYP450 Buspiron (Buspar), Zolpidem (Ambien), Zaleplon (Sonata)
shortens half life of drugs using CYP450-inducer rifampin
lengthens half life of drugs using CYP450-inhibitor erthromycin, Fluoxetine (2D6), Paroxetine (2D6) a
anti-anxiety in patients with hx of abuse Hydroxyzine Vistaril
insomnia treatment Zolpidem, Zaleplon, Eszopiclone, Remalteon Ambien, Sonata, Lunesta, Rozerem
overdoses on amphetamine are tx with chlorpromazine or haloperidol l
only indicated for use in OCD fluvoxamine Prozac
only SSRI that undergoes first pass metabolism Sertraline Zoloft
SSRI with longest half life and active metabolite Fluoxetine Luvox
CYP450 2D6 metabolizes TCA, neuroleptic, some antiarrhythmic and beta adrenergic drugs h
side effects of SSRIs headache, sweating, anxiety/aggitation, GI (nausea, vomiting, diarrhea), weakness/fatigue, sexual dysfunction m
most sedating SSRI paroxetine and fluvoxamine paxil and prozac
most activating SSRIs fluoxetine luvox
antidepressant with little sexual dysfunction bupropion and mirtazapine wellbutrin and ??
serotonin syndrome hyperthermia, muscle rigidity, sweating, myoclonus .
lowest risk for discontinuation syndrome Fluoxetine Luvox
discontinuation syndrome headache, malaise and flu-like sxs, agitation/irritability, nervousness, changes in sleep .
antidepressants that are good for pain venlafaxine and duloxetine (SNRIs and TCAs) effexor and cymbalta
SNRI v TCA SNRI no activity at adrenergic, muscarinic, or histamine
carbidopa decarboxylase inhibitor
levodopa vit B increases peripheral breakdown and diminishes effectiveness
dont use levodopa in patients ____ with glaucoma
patients with glaucoma Levodopa, Benzos
drug-drug interactions levodopa and MAOI --> hypertensive crisis
antipsychotic drug contraindicated parkinsonian patients. sometimes atypicals can be used.
selegiline metabolized into amphetamine = insomnia if taken later than noon
rasagiline 5x more potent than Selegiline without the amphetamine side effects
levodopa-carbidopa side effects diarrhea, postural hypotension, nausea, anorexia, dyskinesia, hallucination, sleep d/o
amantadine antiparkinson. increase release of DA, black cholinergic receptors, inhibits NMDA
alzheimer's treatment 4 AChE inhibitor usually also give memantine
benzos temporarily impair memory
benzos have addiction potential recommend: clonazepam (Klonopin), lorazepam (Ativan), diazepam (Valium)
tx for panic disorder alprazolam
Treatment of muscle spams, MS, and cerebral palsy Diazepam
epilespy treatment Clonazepam
grand mal epileptic seisures and status epilepticus diazepam (Valium) and lorazepam (Ativan)
benzo for sleep: reduce sleep induction time and # of awakenings Flurazepam
benzo for sleep: frequent wakening Temazepam
benzo for sleep: difficulty going to sleep Triazolam
benzos contraindicated liver disease, acute narrow angle glaucoma
Buspirone Buspar
metablized by CYP450 Buspiron (Buspar), Zolpidem (Ambien), Zaleplon (Sonata)
shortens half life of drugs using CYP450-inducer rifampin
lengthens half life of drugs using CYP450-inhibitor erthromycin, Fluoxetine (2D6), Paroxetine (2D6)
anti-anxiety in patients with hx of abuse Hydroxyzine
insomnia treatment Zolpidem, Zaleplon, Eszopiclone, Remalteon
overdoses on amphetamine are tx with chlorpromazine or haloperidol
only indicated for use in OCD fluvoxamine
only SSRI that undergoes first pass metabolism Sertraline
SSRI with longest half life and active metabolite Fluoxetine
CYP450 2D6 metabolizes TCA, neuroleptic, some antiarrhythmic and beta adrenergic drugs
side effects of SSRIs headache, sweating, anxiety/aggitation, GI (nausea, vomiting, diarrhea), weakness/fatigue, sexual dysfunction
most sedating SSRI paroxetine and fluvoxamine
most activating SSRIs fluoxetine
antidepressant with little sexual dysfunction bupropion and mirtazapine
serotonin syndrome hyperthermia, muscle rigidity, sweating, myoclonus
lowest risk for discontinuation syndrome Fluoxetine
discontinuation syndrome headache, malaise and flu-like sxs, agitation/irritability, nervousness, changes in sleep
antidepressants that are good for pain venlafaxine and duloxetine (SNRIs and TCAs)
SNRI v TCA SNRI no activity at adrenergic, muscarinic, or histamine
all antipsychotics are antiemetic except Aripiprazole and thioridazine .
neuroleptic drugs that are cholinergic thioridazine, chlorpromazine ,
neuroleptic drugs that are alpha adrenergic chlorpromazine .
neuroleptics that black H1 chlorpromazine, clozapine .
low risk for EPS clozapine and risperidone block 5HT2a receptors
clozapine agranulocytosis need to monitor white blood cell
contraindicated in patients with seisures chorpromazine and clozapine .
dopamine in the periphery side effects: nausea, vomiting, cardiac arrhythmias, and hypotension
dopamine in the periphery side effects: nausea, vomiting, cardiac arrhythmias, and hypotension
dopamine in the periphery side effects: nausea, vomiting, cardiac arrhythmias, and hypotension
Created by: agdmiles
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