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NSAIDs

TermDefinition
Non selective COX inhibitors 1.Salicylates 2.Propionic acid derivatives 3.Anthranilic acid derivative 4.Aryl acetic acid derivative- 5 .Oxicam derivative 7.Indole derivative 8.Pyrazolone derivative
Salicylates Aspirin --> Acetyl salicylate Diflunisal Sulfasalazine
Propionic acid derivatives Ibuprofen, naproxen, ketoprofen and flurbiprofen
Anthranilic acid derivative Mephenamic acid
Aryl acetic acid derivative Diclofenac and Aceclofenac
Oxicam derivative Piroxicam and Tenoxicam
Indole derivative Indomethacin
Pyrazolone derivative Phenylbutazone and Oxyphenbutazone
selective COX 2 inhibitors celecoxib, etoricoxib and parecoxib COX --> COX 2 ib --> Inhibitor
preferential COX 2 inhibitors Meloxicam
Salicylates MOA Cyclooxygenase converts arachidonic acid into prostaglandins and thromboxane. --> mediators of inflammation COX --> COX-1 and COX-2. COX-1 is expressed in noninflammatory cells. COX-2 is expressed in activated lymphocytes, polymorphonuclear cells.
Non selective COX inhibitors effects Nonselective NSAIDs inhibit both cyclooxygenase isoforms and thereby decrease prostaglandin and thromboxane synthesis Analgesic Anti-inflammation Antipyretic
Adverse effect from therapeutic anti-inflammatory doses of aspirin Gastric upset due to COX-1 inhibition. Chronic use can result in gastric ulceration, upper Gastrointestinal bleeding, and renal effects Increases the bleeding time Experience asthma from the increased synthesis of leukotrienes Tinnitus, vertigo, hyperventilation, and respiratory alkalosis At very high doses, the drug causes metabolic acidosis, dehydration, hyperthermia
MOA of ibuprofen Reversible inhibition of the COX-1 and COX -2
Created by: Jameel D. Wilson
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